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P2rx4 purinergic receptor P2X 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29659, updated on 12-Aug-2018

Summary

Official Symbol
P2rx4provided by RGD
Official Full Name
purinergic receptor P2X 4provided by RGD
Primary source
RGD:62073
See related
Ensembl:ENSRNOG00000001300
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
ATP-activated ionotropic receptor; involved in synaptic transmission in the central nervous system [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 179.0), Kidney (RPKM 171.7) and 9 other tissues See more
Orthologs

Genomic context

See P2rx4 in Genome Data Viewer
Location:
12q16
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39308022..39325673, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (41196777..41214428, complement)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene anaphase-promoting complex subunit 5 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 2 Neighboring gene similar to 60S ribosomal protein L32 Neighboring gene purinergic receptor P2X 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IC
Inferred by Curator
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding ISO
Inferred from Sequence Orthology
more info
 
copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
extracellularly ATP-gated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellularly ATP-gated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
extracellularly ATP-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligand-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ligand-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
purinergic nucleotide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
purinergic nucleotide receptor activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
cation transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to ATP IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to ATP ISO
Inferred from Sequence Orthology
more info
 
cellular response to ATP ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
neuronal action potential IDA
Inferred from Direct Assay
more info
PubMed 
nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion transport into cytosol IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microglial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
purinergic nucleotide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of ruffle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
relaxation of cardiac muscle IEA
Inferred from Electronic Annotation
more info
 
relaxation of cardiac muscle ISO
Inferred from Sequence Orthology
more info
 
response to ATP ISO
Inferred from Sequence Orthology
more info
 
response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IC
Inferred by Curator
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
P2X purinoceptor 4
Names
ATP receptor
P2X4
purinergic receptor P2X, ligand-gated ion channel 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031594.1NP_113782.1  P2X purinoceptor 4

    See identical proteins and their annotated locations for NP_113782.1

    Status: PROVISIONAL

    Source sequence(s)
    X87763
    UniProtKB/Swiss-Prot
    P51577
    Related
    ENSRNOP00000001752.4, ENSRNOT00000001752.5
    Conserved Domains (1) summary
    pfam00864
    Location:13361
    P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    39308022..39325673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    35521444..35539095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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