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Fxyd2 FXYD domain-containing ion transport regulator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29639, updated on 18-Sep-2024

Summary

Official Symbol
Fxyd2provided by RGD
Official Full Name
FXYD domain-containing ion transport regulator 2provided by RGD
Primary source
RGD:2173
See related
EnsemblRapid:ENSRNOG00000016469 AllianceGenome:RGD:2173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ATP1C; Atp1g1; GNAKATP
Summary
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. This gene, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. Related gene family members have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members, with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Two transcript variants have been described for this gene that encode distinct isoforms. [provided by RefSeq, Jan 2010]
Expression
Restricted expression toward (RPKM 3782.6) See more
Orthologs
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Genomic context

See Fxyd2 in Genome Data Viewer
Location:
8q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54609658..54616788)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45712901..45720032)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49710334..49717492)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094137 Neighboring gene FXYD domain-containing ion transport regulator 6 Neighboring gene DS cell adhesion molecule-like 1 Neighboring gene centrosomal protein 164

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ion channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular hyperosmotic salinity response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in inorganic cation transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular potassium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of P-type sodium:potassium-exchanging transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of P-type sodium:potassium-exchanging transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of P-type sodium:potassium-exchanging transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of sodium:potassium-exchanging ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of sodium:potassium-exchanging ATPase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit gamma
Names
ATPase, Na+/K+ transporting, gamma 1 polypeptide
FXTD domain-containing ion transport regulator 2
Na(+)/K(+) ATPase subunit gamma
gamma subunit of sodium potassium ATPase
sodium pump gamma chain
sodium/potassium-transporting ATPase gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017349.3NP_059045.2  sodium/potassium-transporting ATPase subunit gamma isoform b

    See identical proteins and their annotated locations for NP_059045.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) contains an alternate exon in the 5' coding region and 5' UTR, compared to variant a. This results in a shorter protein (isoform b) that has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8L2QTU3, A6J442
    Related
    ENSRNOP00000061133.3, ENSRNOT00000064611.5
    Conserved Domains (1) summary
    cd20318
    Location:850
    FXYD2; FXYD domain-containing ion transport regulator 2
  2. NM_145717.2NP_663769.1  sodium/potassium-transporting ATPase subunit gamma isoform a

    See identical proteins and their annotated locations for NP_663769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) encodes the longer isoform (a).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q04679, Q9JKN3, Q9WUD3
    UniProtKB/TrEMBL
    A0A8L2QTU3, A6J444
    Related
    ENSRNOP00000109670.1, ENSRNOT00000168026.1
    Conserved Domains (1) summary
    cd20318
    Location:1052
    FXYD2; FXYD domain-containing ion transport regulator 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    54609658..54616788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)