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Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29637, updated on 12-Jan-2022

Summary

Official Symbol
Hmgcs1provided by RGD
Official Full Name
3-hydroxy-3-methylglutaryl-CoA synthase 1provided by RGD
Primary source
RGD:70970
See related
Ensembl:ENSRNOG00000016552
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables hydroxymethylglutaryl-CoA synthase activity; isomerase activity; and organic acid binding activity. Involved in several processes, including animal organ development; cellular response to cholesterol; and cellular response to follicle-stimulating hormone stimulus. Located in cytosol. Biomarker of obesity. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Liver (RPKM 1763.9), Brain (RPKM 882.1) and 8 other tissues See more
Orthologs
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Genomic context

See Hmgcs1 in Genome Data Viewer
Location:
2q15
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (51649368..51667100)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (52427351..52445082)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 28 Neighboring gene uncharacterized LOC102547360 Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene uncharacterized LOC120100720

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cholesterol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to follicle-stimulating hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in liver development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cholesterol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to gonadotropin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to low light intensity stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to purine-containing compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to tellurium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
hydroxymethylglutaryl-CoA synthase, cytoplasmic
Names
3-hydroxy-3-methylglutaryl coenzyme A synthase
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
HMG-CoA synthase
hydroxymethylglutaryl-CoA synthase 1
NP_058964.1
XP_006232021.1
XP_038958050.1
XP_038958051.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017268.2NP_058964.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic

    See identical proteins and their annotated locations for NP_058964.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000065
    UniProtKB/Swiss-Prot
    P17425
    Conserved Domains (1) summary
    TIGR01833
    Location:13469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    51649368..51667100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231959.2XP_006232021.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    See identical proteins and their annotated locations for XP_006232021.1

    UniProtKB/Swiss-Prot
    P17425
    Related
    ENSRNOP00000023554.3, ENSRNOT00000023554.7
    Conserved Domains (1) summary
    TIGR01833
    Location:13469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
  2. XM_039102122.1XP_038958050.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    Related
    ENSRNOP00000093563.1, ENSRNOT00000100742.1
    Conserved Domains (1) summary
    TIGR01833
    Location:42498
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
  3. XM_039102123.1XP_038958051.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    Conserved Domains (1) summary
    TIGR01833
    Location:13469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
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