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Gria3 glutamate ionotropic receptor AMPA type subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29628, updated on 19-Apr-2019

Summary

Official Symbol
Gria3provided by RGD
Official Full Name
glutamate ionotropic receptor AMPA type subunit 3provided by RGD
Primary source
RGD:70958
See related
Ensembl:ENSRNOG00000007682
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GLUR3; GluA3; GluR-3; GluR-C; GluR-K3
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
Expression
Biased expression in Adrenal (RPKM 265.0), Brain (RPKM 192.4) and 6 other tissues See more
Orthologs

Genomic context

See Gria3 in Genome Data Viewer
Location:
Xq35
Exon count:
18
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (127561843..127829763)
104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (127655758..127922244)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein ZPR1-like Neighboring gene SET nuclear oncogene-like Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene eukaryotic translation initiation factor 3 subunit K pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
AMPA glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
AMPA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
ionotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
ionotropic glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to fungicide IEP
Inferred from Expression Pattern
more info
PubMed 
response to lithium ion IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
AMPA glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
 
AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
ionotropic glutamate receptor complex TAS
Traceable Author Statement
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
 
parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutamate receptor 3
Names
AMPA-selective glutamate receptor 3
glutamate receptor, ionotrophic, AMPA 3
glutamate receptor, ionotropic, AMPA 3
glutamate receptor, ionotropic, AMPA3 (alpha 3)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112742.1NP_001106213.1  glutamate receptor 3 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate internal coding exon compared to transcript variant 1, and encodes an isoform (2, also known as flop isoform) that is the same length, but with a few amino acid differences from isoform 1. RNA editing (AGA->GGA) changes Arg769Gly.
    Source sequence(s)
    AABR07041368, AABR07041375, BC091324, BF559208, BQ205510, CB713194, DV723256, EV762496, M85036, X54656
    UniProtKB/Swiss-Prot
    P19492
    Related
    ENSRNOP00000031170.6, ENSRNOT00000029031.7
    Conserved Domains (4) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548829
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:40383
    ANF_receptor; Receptor family ligand binding region
  2. NM_032990.2NP_116785.2  glutamate receptor 3 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (AGA->GGA) changes Arg769Gly.
    Source sequence(s)
    AABR07041368, AABR07041375, BC091324, BF559208, BQ205510, CB713194, DV723256, EV762496, X54656
    UniProtKB/Swiss-Prot
    P19492
    Related
    ENSRNOP00000010367.6, ENSRNOT00000010367.6
    Conserved Domains (4) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548829
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:40383
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    127561843..127829763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257498.2XP_006257560.1  glutamate receptor 3 isoform X2

    See identical proteins and their annotated locations for XP_006257560.1

    UniProtKB/TrEMBL
    G3V8Y9
    Conserved Domains (4) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548829
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:40383
    ANF_receptor; Receptor family ligand binding region
  2. XM_017601951.1XP_017457440.1  glutamate receptor 3 isoform X2

    UniProtKB/TrEMBL
    G3V8Y9
    Conserved Domains (4) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548829
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:40383
    ANF_receptor; Receptor family ligand binding region
  3. XM_006257501.3XP_006257563.1  glutamate receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_006257563.1

    UniProtKB/TrEMBL
    G3V6Z5
    Conserved Domains (4) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548829
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:40383
    ANF_receptor; Receptor family ligand binding region
  4. XM_006257496.3XP_006257558.1  glutamate receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_006257558.1

    UniProtKB/TrEMBL
    G3V6Z5
    Conserved Domains (4) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548829
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:40383
    ANF_receptor; Receptor family ligand binding region
  5. XM_017601950.1XP_017457439.1  glutamate receptor 3 isoform X1

    UniProtKB/TrEMBL
    G3V6Z5
    Conserved Domains (4) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548829
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:40383
    ANF_receptor; Receptor family ligand binding region
  6. XM_006257499.2XP_006257561.1  glutamate receptor 3 isoform X3

    Conserved Domains (4) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548802
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:40383
    ANF_receptor; Receptor family ligand binding region

RNA

  1. XR_001842597.1 RNA Sequence

Alternate Rn_Celera

Genomic

  1. AC_000089.1 Alternate Rn_Celera

    Range
    119369614..119631774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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