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Gria2 glutamate ionotropic receptor AMPA type subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29627, updated on 2-Oct-2018

Summary

Official Symbol
Gria2provided by RGD
Official Full Name
glutamate ionotropic receptor AMPA type subunit 2provided by RGD
Primary source
RGD:61862
See related
Ensembl:ENSRNOG00000054204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GluA2; GluR2; gluR-B; GluR-K2
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward (RPKM 706.1) See more
Orthologs

Genomic context

See Gria2 in Genome Data Viewer
Location:
2q33
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (179584302..179704629, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (198991672..199113059, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 198, member B Neighboring gene parkinson protein 7 pseudogene Neighboring gene microRNA 2985 Neighboring gene glycine receptor, beta Neighboring gene platelet derived growth factor C

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
AMPA glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
PDZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
SNARE binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to calcium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
extracellularly glutamate-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ionotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
ionotropic glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
kainate selective glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential EXP
Inferred from Experiment
more info
PubMed 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tetramerization IDA
Inferred from Direct Assay
more info
PubMed 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to fungicide IEP
Inferred from Expression Pattern
more info
PubMed 
response to lithium ion IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
ionotropic glutamate receptor complex TAS
Traceable Author Statement
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
synaptic membrane ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutamate receptor 2
Names
AMPA-selective glutamate receptor 2
glutamate receptor B
glutamate receptor, ionotropic, AMPA 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083811.1NP_001077280.1  glutamate receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001077280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to transcript variant 1, and encodes an isoform (2, also known as the flop isoform) that is the same length as isoform 1, but with few amino acid differences. RNA editing changes Gln607Arg (CAG->CGG) and Arg764Gly (AGA->GGA).
    Source sequence(s)
    AABR07072744, AF164344, CO400088, M38061, M85035
    UniProtKB/Swiss-Prot
    P19491
    Related
    ENSRNOP00000069094.1, ENSRNOT00000077941.1
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
  2. NM_017261.2NP_058957.1  glutamate receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_058957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as the flip isoform). RNA editing changes Gln607Arg (CAG->CGG) and Arg764Gly (AGA->GGA).
    Source sequence(s)
    AABR07072744, AF164344, CO400088, M38061
    UniProtKB/Swiss-Prot
    P19491
    Related
    ENSRNOP00000072906.1, ENSRNOT00000083361.1
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    179584302..179704629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    159991989..160110044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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