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Gria2 glutamate ionotropic receptor AMPA type subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29627, updated on 8-Dec-2022

Summary

Official Symbol
Gria2provided by RGD
Official Full Name
glutamate ionotropic receptor AMPA type subunit 2provided by RGD
Primary source
RGD:61862
See related
Ensembl:ENSRNOG00000054204 AllianceGenome:RGD:61862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GluA2; GluR2; gluR-B; GluR-K2
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward (RPKM 706.1) See more
Orthologs
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Genomic context

See Gria2 in Genome Data Viewer
Location:
2q33
Exon count:
17
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (165949379..166069510, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (179584302..179704629, complement)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene golgi associated kinase 1B Neighboring gene Parkinsonism associated deglycase, pseudogene 3 Neighboring gene small nucleolar RNA SNORA9 Neighboring gene microRNA 2985 Neighboring gene glycine receptor, beta Neighboring gene RNA, U7 small nuclear 62 Neighboring gene platelet derived growth factor C

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables AMPA glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables AMPA glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SNARE binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables extracellularly glutamate-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables immunoglobulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ionotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ionotropic glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kainate selective glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to brain-derived neurotrophic factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to glycine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cerebral cortex development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ionotropic glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein tetramerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to fungicide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lithium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine head IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine neck IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
part_of ionotropic glutamate receptor complex TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perisynaptic space ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
located_in spine synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutamate receptor 2
Names
AMPA-selective glutamate receptor 2
glutamate receptor B
glutamate receptor, ionotropic, AMPA 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083811.1NP_001077280.1  glutamate receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001077280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to transcript variant 1, and encodes an isoform (2, also known as the flop isoform) that is the same length as isoform 1, but with few amino acid differences. RNA editing changes Gln607Arg (CAG->CGG) and Arg764Gly (AGA->GGA).
    Source sequence(s)
    AF164344, CO400088, JACYVU010000069, M38061, M85035
    UniProtKB/Swiss-Prot
    P19491
    Related
    ENSRNOP00000069094.2, ENSRNOT00000077941.2
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
  2. NM_017261.2NP_058957.1  glutamate receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_058957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as the flip isoform). RNA editing changes Gln607Arg (CAG->CGG) and Arg764Gly (AGA->GGA).
    Source sequence(s)
    AF164344, CO400088, JACYVU010000069, M38061
    UniProtKB/Swiss-Prot
    P19491
    Related
    ENSRNOP00000072906.2, ENSRNOT00000083361.2
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    165949379..166069510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)