Angpt4 angiopoietin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Angpt4provided by RGD
Official Full Name: angiopoietin 4provided by RGD
Primary source: RGD:1307539
See related: Ensembl:ENSRNOG00000005008 AllianceGenome:RGD:1307539
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Agpt4
Summary: Predicted to enable receptor tyrosine kinase binding activity and transmembrane receptor protein tyrosine kinase activator activity. Predicted to be involved in several processes, including positive regulation of peptidyl-tyrosine phosphorylation; regulation of angiogenesis; and regulation of blood vessel endothelial cell migration. Predicted to act upstream of or within Notch signaling pathway. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPT4 (angiopoietin 4). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Adrenal (RPKM 8.2), Thymus (RPKM 4.2) and 8 other tissues See more
Orthologs: all
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Genomic context

Location:: 3q41

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (160880539..160913923)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (140420389..140454213)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (147421724..147455670)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration.
Title: Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Tie signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
NOT involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiopoietin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106526.1 → NP_001099996.1 angiopoietin-4 precursor

See identical proteins and their annotated locations for NP_001099996.1

Status: PROVISIONAL

Source sequence(s)

CH474050

UniProtKB/TrEMBL

A6KHL3, D3ZR43

Related

ENSRNOP00000006786.4, ENSRNOT00000006786.8

Conserved Domains (1) summary

cd00087
Location:291 → 506

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

160880539..160913923

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104603.2 → XP_038960531.1 angiopoietin-4 isoform X4

Conserved Domains (2) summary

cd00087
Location:291 → 412

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

TIGR02169
Location:98 → 233

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
XM_039104601.2 → XP_038960529.1 angiopoietin-4 isoform X2

Conserved Domains (1) summary

cd00087
Location:291 → 415

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_039104600.2 → XP_038960528.1 angiopoietin-4 isoform X1

UniProtKB/TrEMBL

A0ABK0M4K9

Related

ENSRNOP00000112081.1, ENSRNOT00000154537.1

Conserved Domains (2) summary

cd00087
Location:291 → 472

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

TIGR02169
Location:98 → 233

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
XM_063283363.1 → XP_063139433.1 angiopoietin-4 isoform X6
XM_039104602.2 → XP_038960530.1 angiopoietin-4 isoform X3

Conserved Domains (2) summary

COG4372
Location:17 → 127

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

cd00087
Location:188 → 403

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_039104604.2 → XP_038960532.1 angiopoietin-4 isoform X5

Conserved Domains (2) summary

COG4372
Location:3 → 113

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

cd00087
Location:174 → 389

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...