Crhbp corticotropin releasing hormone binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crhbpprovided by RGD
Official Full Name: corticotropin releasing hormone binding proteinprovided by RGD
Primary source: RGD:2403
See related: Ensembl:ENSRNOG00000017890 AllianceGenome:RGD:2403
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Crfbp
Summary: Enables corticotropin-releasing hormone binding activity and peptide binding activity. Involved in several processes, including cellular response to cocaine; cellular response to estradiol stimulus; and cellular response to estrogen stimulus. Located in several cellular components, including axon; cytoplasmic vesicle; and perikaryon. Biomarker of depressive disorder; obesity; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in depressive disorder and opioid abuse. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward (RPKM 45.4) See more
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Location:: 2q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (28427139..28439446, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (26692403..26704710, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (25141471..25153334, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

show that CRF-BP physically interacts with the CRF2alphaR but not the CRF2betaR isoform, increasing CRF2alphaR on the cell surface. Thus, CRF-BP emerges as a GPCR escort protein increasing the understanding of GPCR trafficking
Title: CRF binding protein facilitates the presence of CRF type 2α receptor on the cell surface.
Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein mRNA and protein are expressed in the lateral hypothalamic area, and that both proteins are present in orexin-positive ventral tegmental area synaptosomes.
Title: Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein coexist in rat ventral tegmental area nerve terminals originated in the lateral hypothalamic area.
Results show that CRF-BP is efficiently sorted to the regulated secretory pathway in two cellular contexts, suggesting that the extracellular levels of CRF-BP in the central nervous system depends on neuronal activity.
Title: Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons.
The present studies revealed a role of VTA CRF-BP and suggest an involvement of CRF(2)R in the effectiveness of stress in triggering glutamate and dopamine release and cocaine seeking in drug-experienced animals.
Title: Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat.
alterations in basolateral amygdala CRF-BP gene expression are a primary response of the basolateral/central CRF system to acute stress
Title: The effects of acute stress on the regulation of central and basolateral amygdala CRF-binding protein gene expression.
The binding protein of corticotropin-releasing factor: ligand-binding site and subunit structure.
Title: The binding protein of corticotropin-releasing factor: ligand-binding site and subunit structure.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH132846 (e-PCR)
- UniSTS:216129

D2Wox56 (e-PCR)
- UniSTS:240053

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables corticotropin-releasing hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables corticotropin-releasing hormone binding	IEA Inferred from Electronic Annotation more info
enables corticotropin-releasing hormone binding	IPI Inferred from Physical Interaction more info	PubMed
enables corticotropin-releasing hormone binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in behavioral response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to ethanol	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cocaine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estradiol stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin-releasing hormone	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin-releasing hormone	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to immobilization stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to potassium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in maternal aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal aggressive behavior	ISO Inferred from Sequence Orthology more info
involved_in maternal aggressive behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in maternal behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal locomotion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of corticotropin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of corticotropin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulated exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of NMDA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of NMDA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of corticotropin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic transmission, dopaminergic	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, dopaminergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
NOT located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
NOT located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
NOT located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in secondary lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISS Inferred from Sequence or Structural Similarity more info
located_in varicosity	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: corticotropin-releasing factor-binding protein

Names: CRF-BP; CRF-binding protein; CRH-BP

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139183.2 → NP_631922.1 corticotropin-releasing factor-binding protein precursor

See identical proteins and their annotated locations for NP_631922.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P24388

UniProtKB/TrEMBL

F7EU31, O35761

Related

ENSRNOP00000024191.3, ENSRNOT00000024191.6

Conserved Domains (1) summary

pfam05428
Location:1 → 307

CRF-BP; Corticotropin-releasing factor binding protein (CRF-BP)