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Cyss cystatin S [ Rattus norvegicus (Norway rat) ]

Gene ID: 296234, updated on 2-Oct-2018

Summary

Symbol
Cyssprovided by RGD
Full Name
cystatin Sprovided by RGD
Primary source
RGD:735160
See related
Ensembl:ENSRNOG00000030857 Vega:OTTRNOG00000000990
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cst4
Summary
cysteine proteinase inhibitor; may be regulated by cAMP mediated signaling and by estrogen [RGD, Feb 2006]
Expression
Low expression observed in reference dataset See more

Genomic context

See Cyss in Genome Data Viewer
Location:
3q41
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (144427430..144431768, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (150801395..150805733, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene androgen regulated protein Neighboring gene similar to Cystatin S precursor (LM protein) Neighboring gene similar to Cystatin S precursor (LM protein) Neighboring gene similar to Cystatin S precursor (LM protein)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cysteine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protease binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell development IEP
Inferred from Expression Pattern
more info
PubMed 
cell killing IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
response to axon injury IEP
Inferred from Expression Pattern
more info
PubMed 
response to chromate IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to protozoan IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
salivary gland development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cystatin-S
Names
LM protein
cystatin-1
protein LM

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198685.1NP_941958.1  cystatin-S precursor

    See identical proteins and their annotated locations for NP_941958.1

    Status: PROVISIONAL

    Source sequence(s)
    M75281
    UniProtKB/Swiss-Prot
    P19313
    Related
    ENSRNOP00000044719.1, OTTRNOP00000000850, ENSRNOT00000044345.2, OTTRNOT00000001514
    Conserved Domains (1) summary
    smart00043
    Location:31139
    CY; Cystatin-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    144427430..144431768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    136119326..136123644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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