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Pecam1 platelet and endothelial cell adhesion molecule 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29583, updated on 21-Jul-2020

Summary

Official Symbol
Pecam1provided by RGD
Official Full Name
platelet and endothelial cell adhesion molecule 1provided by RGD
Primary source
RGD:61927
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CD31; Pecam
Summary
cell adhesion molecule, also intracellular signaling molecule; may mediate leukocyte adhesion and migration, angiogenesis, and thrombosis [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Expression
Biased expression in Lung (RPKM 947.0), Heart (RPKM 570.7) and 8 other tissues See more
Orthologs

Genomic context

See Pecam1 in Genome Data Viewer
Location:
10q32.1
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94850971..94913202, complement)
106 current Rn_Celera (GCF_000002265.2) 10 AC_000078.1 (90260186..90318290, complement)
106 current Rn_Celera (GCF_000002265.2) Unplaced Scaffold NW_001088142.1 (838..1162, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (94598951..94660385, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene testis expressed 2 Neighboring gene uncharacterized LOC108352148 Neighboring gene mast cell immunoglobulin-like receptor 1 Neighboring gene DNA polymerase gamma 2, accessory subunit

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC124998

Gene Ontology Provided by RGD

Function Evidence Code Pubs
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-gamma IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
diapedesis ISO
Inferred from Sequence Orthology
more info
 
endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
endothelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endothelial cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
glomerular endothelium development ISO
Inferred from Sequence Orthology
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
monocyte extravasation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
 
phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
smooth muscle contractile fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
platelet endothelial cell adhesion molecule
Names
PECAM-1
platelet/endothelial cell adhesion molecule 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031591.1NP_113779.1  platelet endothelial cell adhesion molecule precursor

    See identical proteins and their annotated locations for NP_113779.1

    Status: PROVISIONAL

    Source sequence(s)
    BC104711
    UniProtKB/Swiss-Prot
    Q3SWT0
    Conserved Domains (3) summary
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:317393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33117
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    94850971..94913202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    90260186..90318290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. NW_001088142.1 Alternate Rn_Celera

    Range
    838..1162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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