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Fdft1 farnesyl diphosphate farnesyl transferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29580, updated on 13-Aug-2019

Summary

Official Symbol
Fdft1provided by RGD
Official Full Name
farnesyl diphosphate farnesyl transferase 1provided by RGD
Primary source
RGD:61834
See related
Ensembl:ENSRNOG00000021314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes the conversion of trans-farnesyl diphosphate to squalene; plays a role in biosynthesis of cholesterol and of isoprenoids [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 258.9), Kidney (RPKM 209.9) and 9 other tissues See more
Orthologs

Genomic context

See Fdft1 in Genome Data Viewer
Location:
15p12
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46339248..46367302, complement)
106 current Rn_Celera (GCF_000002265.2) 15 AC_000083.1 (37096417..37124524, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (50104042..50132096, complement)

Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108353035 Neighboring gene cathepsin B Neighboring gene nei-like DNA glycosylase 2 Neighboring gene GATA binding protein 4 Neighboring gene uncharacterized LOC102548615

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC93486

Gene Ontology Provided by RGD

Function Evidence Code Pubs
farnesyl-diphosphate farnesyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
farnesyl-diphosphate farnesyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
farnesyl-diphosphate farnesyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
squalene synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
ergosterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
farnesyl diphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
farnesyl diphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
squalene synthase
Names
FPP:FPP farnesyltransferase
SQS
SS
farnesyl diphosphate farnesyltransferase
squalene synthetase
NP_062111.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019238.2NP_062111.1  squalene synthase

    See identical proteins and their annotated locations for NP_062111.1

    Status: VALIDATED

    Source sequence(s)
    AABR07018195, BC081810, BE104849
    UniProtKB/Swiss-Prot
    Q02769
    Related
    ENSRNOP00000029808.3, ENSRNOT00000032089.4
    Conserved Domains (1) summary
    cl00210
    Location:39370
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005114.4 Reference Rnor_6.0 Primary Assembly

    Range
    46339248..46367302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000083.1 Alternate Rn_Celera

    Range
    37096417..37124524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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