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GTF2A2 general transcription factor IIA subunit 2 [ Homo sapiens (human) ]

Gene ID: 2958, updated on 26-Nov-2021

Summary

Official Symbol
GTF2A2provided by HGNC
Official Full Name
general transcription factor IIA subunit 2provided by HGNC
Primary source
HGNC:HGNC:4647
See related
Ensembl:ENSG00000140307 MIM:600519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF2A2; TFIIA; T18745; TFIIAS; HsT18745; TFIIA-12; TFIIA-gamma
Summary
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 46.4), colon (RPKM 13.2) and 24 other tissues See more
Orthologs
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Genomic context

See GTF2A2 in Genome Data Viewer
Location:
15q22.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (59638062..59657515, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59930261..59949714, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 396 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene BCL2 interacting protein 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class H pseudogene 1 Neighboring gene RPS3A pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIIA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription factor TFIIA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIIA complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor IIA subunit 2
Names
TFIIA gamma subunit
TFIIA p12 subunit
general transcription factor IIA 2
general transcription factor IIA, 2, 12kDa
transcription initiation factor IIA gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320929.2NP_001307858.1  transcription initiation factor IIA subunit 2

    Status: VALIDATED

    Source sequence(s)
    AC092755, BX099306, HY002503, HY036972
    Consensus CDS
    CCDS10173.1
    UniProtKB/Swiss-Prot
    P52657
    UniProtKB/TrEMBL
    A0A024R5Z5
    Related
    ENSP00000379373.1, ENST00000396061.5
    Conserved Domains (1) summary
    COG5123
    Location:3103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]
  2. NM_001320930.2NP_001307859.1  transcription initiation factor IIA subunit 2

    Status: VALIDATED

    Source sequence(s)
    AC092755, BX099306, CB156109
    Consensus CDS
    CCDS10173.1
    UniProtKB/Swiss-Prot
    P52657
    UniProtKB/TrEMBL
    A0A024R5Z5
    Related
    ENSP00000379375.1, ENST00000396063.5
    Conserved Domains (1) summary
    COG5123
    Location:3103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]
  3. NM_004492.3NP_004483.1  transcription initiation factor IIA subunit 2

    See identical proteins and their annotated locations for NP_004483.1

    Status: VALIDATED

    Source sequence(s)
    AK312015, BC000287, CV572751, DB531003
    Consensus CDS
    CCDS10173.1
    UniProtKB/Swiss-Prot
    P52657
    UniProtKB/TrEMBL
    A0A024R5Z5, B2R506
    Related
    ENSP00000379372.2, ENST00000396060.7
    Conserved Domains (1) summary
    COG5123
    Location:3103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    59638062..59657515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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