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Prps1 phosphoribosyl pyrophosphate synthetase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29562, updated on 8-Jul-2018
Official Symbol
Prps1provided by RGD
Official Full Name
phosphoribosyl pyrophosphate synthetase 1provided by RGD
Primary source
RGD:61955
See related
Ensembl:ENSRNOG00000060262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may phosphorylate ribose [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 220.7), Muscle (RPKM 151.5) and 9 other tissues See more
Orthologs
See Prps1 in Genome Data Viewer
Location:
Xq32
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (111798233..111820270)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (52779462..52801499, complement)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene nucleoporin 62 C-terminal like Neighboring gene PIH1 domain containing 3 Neighboring gene FERM and PDZ domain containing 3 Neighboring gene TSC22 domain family, member 3 Neighboring gene similar to 60S ribosomal protein L23a

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016
  • Biosynthesis of amino acids, organism-specific biosystem (from KEGG)
    Biosynthesis of amino acids, organism-specific biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Biosynthesis of amino acids, conserved biosystem (from KEGG)
    Biosynthesis of amino acids, conserved biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Nucleotide Metabolism, organism-specific biosystem (from WikiPathways)
    Nucleotide Metabolism, organism-specific biosystem
    Nucleotide Metabolism
  • PRPP biosynthesis, organism-specific biosystem (from BIOCYC)
    PRPP biosynthesis, organism-specific biosystemBackground : PRPP "PRPP" is an important substrate in the synthesis of purine, pyrimidine, and pyridine nucleotides . About this Pathway At least three enzymes, : CPLX66-360, : CPLX66-359 and : C...
  • PRPP biosynthesis I, conserved biosystem (from BIOCYC)
    PRPP biosynthesis I, conserved biosystem|FRAME: PRPP| may be synthesized from ribose 5-phosphate by |FRAME: PRPPSYN-MONOMER| or, alternately, by the the enzymes |FRAME: PPENTOMUT-MONOMER|, |FRAME: MONOMER0-702| (putative), and |FRAME: EG10...
  • PRPP biosynthesis, ribose 5P => PRPP, organism-specific biosystem (from KEGG)
    PRPP biosynthesis, ribose 5P => PRPP, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
  • PRPP biosynthesis, ribose 5P => PRPP, conserved biosystem (from KEGG)
    PRPP biosynthesis, ribose 5P => PRPP, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
  • Pentose phosphate pathway, organism-specific biosystem (from KEGG)
    Pentose phosphate pathway, organism-specific biosystemThe pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathwa...
  • Pentose phosphate pathway, conserved biosystem (from KEGG)
    Pentose phosphate pathway, conserved biosystemThe pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathwa...
  • Purine metabolism, organism-specific biosystem (from KEGG)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, conserved biosystem (from KEGG)
    Purine metabolism, conserved biosystem
    Purine metabolism
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
AMP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ribose phosphate diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribose phosphate diphosphokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
ribose phosphate diphosphokinase activity ISO
Inferred from Sequence Orthology
more info
 
ribose phosphate diphosphokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
5-phosphoribose 1-diphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
5-phosphoribose 1-diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
AMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
hypoxanthine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
hypoxanthine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
 
nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
purine nucleobase metabolic process ISO
Inferred from Sequence Orthology
more info
 
purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
purine nucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
ribose phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
urate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
urate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ribose phosphate diphosphokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribose phosphate diphosphokinase complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ribose-phosphate pyrophosphokinase 1
Names
PRS-I
phosphoribosyl pyrophosphate synthase I
phosphoribosyl pyrophosphate synthetase I
NP_058939.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017243.2NP_058939.1  ribose-phosphate pyrophosphokinase 1

    See identical proteins and their annotated locations for NP_058939.1

    Status: VALIDATED

    Source sequence(s)
    CB702494, CK841243, CO405720, X16554
    UniProtKB/Swiss-Prot
    P60892
    Related
    ENSRNOP00000071101.1, ENSRNOT00000078582.1
    Conserved Domains (1) summary
    COG0462
    Location:1313
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    111798233..111820270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    43777612..43799661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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