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Fcgrt Fc gamma receptor and transporter [ Rattus norvegicus (Norway rat) ]

Gene ID: 29558, updated on 17-Aug-2024

Summary

Official Symbol
Fcgrtprovided by RGD
Official Full Name
Fc gamma receptor and transporterprovided by RGD
Primary source
RGD:61811
See related
EnsemblRapid:ENSRNOG00000020583 AllianceGenome:RGD:61811
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FcRn
Summary
Enables beta-2-microglobulin binding activity. Predicted to be involved in immune response. Predicted to be located in endosome membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to human FCGRT (Fc fragment of IgG receptor and transporter). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 652.1), Spleen (RPKM 643.6) and 9 other tissues See more
Orthologs
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Genomic context

See Fcgrt in Genome Data Viewer
Location:
1q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104710902..104720685, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95574436..95584171, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101086872..101096159, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene proline rich and Gla domain 2 Neighboring gene nitric oxide synthase interacting protein Neighboring gene reticulocalbin 3 Neighboring gene small nucleolar RNA, C/D box 35B Neighboring gene microRNA 150 Neighboring gene ribosomal protein S11

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables IgG binding IEA
Inferred from Electronic Annotation
more info
 
enables IgG binding ISO
Inferred from Sequence Orthology
more info
 
enables IgG receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables beta-2-microglobulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-2-microglobulin binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables peptide antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in humoral immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
IgG receptor FcRn large subunit p51
Names
Fc fragment immunoglobulin G receptor
Fc fragment of IgG receptor and transporter
Fc fragment of IgG, receptor, transporter, alpha
Fc receptor, IgG, alpha chain transporter
igG Fc fragment receptor transporter alpha chain
neonatal Fc receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033351.2NP_203502.1  IgG receptor FcRn large subunit p51 precursor

    See identical proteins and their annotated locations for NP_203502.1

    Status: PROVISIONAL

    Source sequence(s)
    M35495
    UniProtKB/Swiss-Prot
    P13599
    UniProtKB/TrEMBL
    A0A8L2QEY2, A6JAW9
    Conserved Domains (2) summary
    pfam00129
    Location:25198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cd21011
    Location:199291
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104710902..104720685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229043.4XP_006229105.1  IgG receptor FcRn large subunit p51 isoform X1

    See identical proteins and their annotated locations for XP_006229105.1

    UniProtKB/Swiss-Prot
    P13599
    UniProtKB/TrEMBL
    A0A8L2QEY2, A6JAW9
    Related
    ENSRNOP00000027944.6, ENSRNOT00000027944.8
    Conserved Domains (2) summary
    pfam00129
    Location:25198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cd21011
    Location:199291
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
  2. XM_039109580.1XP_038965508.1  IgG receptor FcRn large subunit p51 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GKP0
    Related
    ENSRNOP00000093469.1, ENSRNOT00000104770.2
    Conserved Domains (2) summary
    cd21011
    Location:110199
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
    cl08246
    Location:25110
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  3. XM_017589060.2XP_017444549.1  IgG receptor FcRn large subunit p51 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QEY2
    Conserved Domains (2) summary
    cd21011
    Location:170262
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
    cl08246
    Location:1169
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  4. XM_039109565.2XP_038965493.1  IgG receptor FcRn large subunit p51 isoform X1

    UniProtKB/Swiss-Prot
    P13599
    UniProtKB/TrEMBL
    A0A8L2QEY2, A6JAW9
    Conserved Domains (2) summary
    pfam00129
    Location:25198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cd21011
    Location:199291
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
  5. XM_063287635.1XP_063143705.1  IgG receptor FcRn large subunit p51 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GKP0