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Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29554, updated on 30-Aug-2020

Summary

Official Symbol
Pdha1provided by RGD
Official Full Name
pyruvate dehydrogenase E1 subunit alpha 1provided by RGD
Primary source
RGD:3286
See related
Ensembl:ENSRNOG00000025383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes the interconversion of pyruvate and lipoamide to S-acetyldihydrolipoamide and CO2 [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 2912.9), Muscle (RPKM 2115.2) and 8 other tissues See more
Orthologs

Genomic context

See Pdha1 in Genome Data Viewer
Location:
Xq14
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (37329779..37343410)
106 current Rn_Celera (GCF_000002265.2) X AC_000089.1 (35373056..35386884)
104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (37640725..37654356)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555147 Neighboring gene RhoA activator C11orf59-like Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene ribosomal protein S6 kinase A3 Neighboring gene eukaryotic translation initiation factor 1A, X-linked

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC94854, MGC114215

Gene Ontology Provided by RGD

Function Evidence Code Pubs
pyruvate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
pyruvate dehydrogenase (acetyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyruvate dehydrogenase (acetyl-transferring) activity IDA
Inferred from Direct Assay
more info
PubMed 
pyruvate dehydrogenase (acetyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
 
pyruvate dehydrogenase (acetyl-transferring) activity ISO
Inferred from Sequence Orthology
more info
 
pyruvate dehydrogenase (acetyl-transferring) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
pyruvate dehydrogenase (acetyl-transferring) activity TAS
Traceable Author Statement
more info
PubMed 
pyruvate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetyl-CoA biosynthetic process from pyruvate IDA
Inferred from Direct Assay
more info
PubMed 
acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 
acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
mitochondrial acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
mitochondrial pyruvate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial pyruvate dehydrogenase complex TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
pyruvate dehydrogenase complex IDA
Inferred from Direct Assay
more info
PubMed 
pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Names
PDHE1-A type I
pyruvate dehydrogenase (lipoamide) alpha 1
pyruvate dehydrogenase E1 alpha 1 subunit
pyruvate dehydrogenase E1alpha subunit
pyruvate dehydrogenase alpha 1
NP_001004072.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004072.2NP_001004072.2  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001004072.2

    Status: VALIDATED

    Source sequence(s)
    BC098897
    UniProtKB/TrEMBL
    Q4FZZ4
    Related
    ENSRNOP00000030279.6, ENSRNOT00000038352.6
    Conserved Domains (1) summary
    TIGR03182
    Location:58370
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    37329779..37343410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000089.1 Alternate Rn_Celera

    Range
    35373056..35386884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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