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Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29554, updated on 2-May-2024

Summary

Official Symbol
Pdha1provided by RGD
Official Full Name
pyruvate dehydrogenase E1 subunit alpha 1provided by RGD
Primary source
RGD:3286
See related
Ensembl:ENSRNOG00000025383 AllianceGenome:RGD:3286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Used to study pyruvate decarboxylase deficiency. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 2912.9), Muscle (RPKM 2115.2) and 8 other tissues See more
Orthologs
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Genomic context

See Pdha1 in Genome Data Viewer
Location:
Xq14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (38509158..38522986)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (34700481..34714309)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (37329779..37343410)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA55 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1 Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene ubiquitin-like 4A, pseudogene Neighboring gene SH3 domain-containing kinase-binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC94854, MGC114215

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
part_of pyruvate dehydrogenase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Names
PDHE1-A type I
pyruvate dehydrogenase (lipoamide) alpha 1
pyruvate dehydrogenase E1 alpha 1 subunit
pyruvate dehydrogenase E1alpha subunit
pyruvate dehydrogenase alpha 1
NP_001004072.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004072.2NP_001004072.2  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001004072.2

    Status: VALIDATED

    Source sequence(s)
    BC098897
    UniProtKB/Swiss-Prot
    P26284
    UniProtKB/TrEMBL
    Q4FZZ4
    Related
    ENSRNOP00000030279.7, ENSRNOT00000038352.7
    Conserved Domains (1) summary
    TIGR03182
    Location:58370
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    38509158..38522986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)