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Homer3 homer scaffold protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29548, updated on 19-Apr-2019

Summary

Official Symbol
Homer3provided by RGD
Official Full Name
homer scaffold protein 3provided by RGD
Primary source
RGD:620706
See related
Ensembl:ENSRNOG00000020229
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Vesl-3
Summary
may interact with group I metabotropic glutamate receptors and regulate their coupling to membrane ion channels [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 88.9), Adrenal (RPKM 88.3) and 9 other tissues See more
Orthologs

Genomic context

See Homer3 in Genome Data Viewer
Location:
16p14
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20880447..20890968, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (20732220..20742730, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene UPF1, RNA helicase and ATPase Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene coatomer protein complex, subunit epsilon Neighboring gene DEAD-box helicase 49 Neighboring gene SURP and G patch domain containing 2 Neighboring gene transmembrane protein 60-like Neighboring gene armadillo repeat containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G protein-coupled glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of calcineurin-NFAT signaling cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of interleukin-2 production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of postsynaptic neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basal part of cell IEA
Inferred from Electronic Annotation
more info
 
basal part of cell ISO
Inferred from Sequence Orthology
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homer protein homolog 3
Names
VASP/Ena-related gene up-regulated during seizure and LTP 3
homer homolog 3
homer scaffolding protein 3
homer, neuronal immediate early gene, 3
homer-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053310.1NP_445762.1  homer protein homolog 3

    See identical proteins and their annotated locations for NP_445762.1

    Status: PROVISIONAL

    Source sequence(s)
    AB020879
    UniProtKB/Swiss-Prot
    Q9Z2X5
    Related
    ENSRNOP00000027428.4, ENSRNOT00000027428.5
    Conserved Domains (1) summary
    cd01206
    Location:6114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    20880447..20890968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252890.3XP_006252952.1  homer protein homolog 3 isoform X1

    Conserved Domains (1) summary
    cd01206
    Location:6114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
  2. XM_006252891.3XP_006252953.1  homer protein homolog 3 isoform X4

    See identical proteins and their annotated locations for XP_006252953.1

    UniProtKB/Swiss-Prot
    Q9Z2X5
    Conserved Domains (1) summary
    cd01206
    Location:6114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
  3. XM_008771095.2XP_008769317.1  homer protein homolog 3 isoform X3

    Conserved Domains (1) summary
    cd01206
    Location:6114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
  4. XM_008771094.2XP_008769316.1  homer protein homolog 3 isoform X2

    Conserved Domains (1) summary
    cd01206
    Location:6114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    19323520..19330908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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