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Tbck TBC1 domain containing kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 295446, updated on 13-Apr-2024

Summary

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Official Symbol
Tbckprovided by RGD
Official Full Name
TBC1 domain containing kinaseprovided by RGD
Primary source
RGD:1307816
See related
Ensembl:ENSRNOG00000011454 AllianceGenome:RGD:1307816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tbckl; RGD1307816
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including activation of GTPase activity; intracellular protein transport; and regulation of TOR signaling. Predicted to be located in cytoplasm; midbody; and mitotic spindle. Orthologous to human TBCK (TBC1 domain containing kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 77.1), Lung (RPKM 56.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q43
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (223849758..224022097)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (221175749..221348058)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (237751646..237958497)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547683 Neighboring gene GIMAP family P-loop NTPase domain containing 1 Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nephronectin Neighboring gene MTOR associated protein, eak-7 homolog, pseudogene 1 Neighboring gene uncharacterized LOC102548236

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A long type of TBCK is a novel cytoplasmic and mitotic apparatus-associated protein likely suppressing cell proliferation. Wu J, et al. J Genet Genomics, 2014 Feb 20. PMID 24576458
  2. TBCK influences cell proliferation, cell size and mTOR signaling pathway. Liu Y, et al. PLoS One, 2013. PMID 23977024, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TBC domain-containing protein kinase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415033.1 → NP_001401962.1  TBC domain-containing protein kinase-like protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2K9Q0
    Related
    ENSRNOP00000075082.1, ENSRNOT00000083937.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    223849758..224022097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102101.2 → XP_038958029.1  TBC domain-containing protein kinase-like protein isoform X2

    Conserved Domains (3) summary
    COG5210
    Location:335 → 546
    COG5210; GTPase-activating protein [General function prediction only]
    cl02495
    Location:467 → 546
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl21453
    Location:43 → 273
    PKc_like; Protein Kinases, catalytic domain

  2. XM_063281663.1 → XP_063137733.1  TBC domain-containing protein kinase-like protein isoform X1

  3. XM_039102098.2 → XP_038958026.1  TBC domain-containing protein kinase-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALH8
    Conserved Domains (3) summary
    smart00164
    Location:328 → 532
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl00125
    Location:633 → 744
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    cl21453
    Location:11 → 134
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134513.1: Suppressed sequence

    Description
    NM_001134513.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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