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Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295443, updated on 24-Jul-2025
Official Symbol
Papss1provided by RGD
Official Full Name
3'-phosphoadenosine 5'-phosphosulfate synthase 1provided by RGD
Primary source
RGD:1308081
See related
Ensembl:ENSRNOG00000011311 AllianceGenome:RGD:1308081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable adenylylsulfate kinase activity; protein homodimerization activity; and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process and sulfate assimilation. Predicted to be active in cytosol and nucleus. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Kidney (RPKM 344.7), Brain (RPKM 246.4) and 9 other tissues See more
Orthologs
human mouse all
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See Papss1 in Genome Data Viewer
Location:
2q43
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (222646103..222788475)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (220040343..220114399)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (236605695..236680772)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485686 Neighboring gene uncharacterized LOC108350108 Neighboring gene sphingomyelin synthase 2 Neighboring gene uncharacterized LOC134485969 Neighboring gene uncharacterized LOC120100944 Neighboring gene uncharacterized LOC134485970 Neighboring gene polysaccharide biosynthesis domain containing 1, pseudogene 2 Neighboring gene RNA, variant U1 small nuclear 6 Neighboring gene actin related protein 10, pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Expression, purification and crystallization of human 3'-phosphoadenosine-5'-phosphosulfate synthetase 1. Harjes S, et al. Acta Crystallogr D Biol Crystallogr, 2004 Feb. PMID 14747722
  2. Identification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase. Singh B, et al. J Biol Chem, 2003 Jan 3. PMID 12414806
  3. Ethanol sulfation by the human cytosolic sulfotransferases: a systematic analysis. Kurogi K, et al. Biol Pharm Bull, 2012. PMID 23207770
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylylsulfate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylylsulfate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylylsulfate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate adenylyltransferase (ATP) activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate adenylyltransferase (ATP) activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate assimilation IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
NP_001381988.1
XP_063137732.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395059.1 → NP_001381988.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2K0L0, B2RYI8
    Related
    ENSRNOP00000071489.2, ENSRNOT00000085301.3
    Conserved Domains (2) summary
    cd00517
    Location:254 → 617
    ATPS; ATP-sulfurylase
    pfam01583
    Location:51 → 205
    APS_kinase; Adenylylsulphate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    222646103..222788475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281662.1 → XP_063137732.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0L0, B2RYI8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106471.1: Suppressed sequence

    Description
    NM_001106471.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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