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Timp2 TIMP metallopeptidase inhibitor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29543, updated on 30-Sep-2021

Summary

Official Symbol
Timp2provided by RGD
Official Full Name
TIMP metallopeptidase inhibitor 2provided by RGD
Primary source
RGD:61312
See related
EnsemblRapid:ENSRNOG00000033143
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
acts as an inhibitor of metallopeptidase activity; may play a role in tissue remodeling during spermatogenesis [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 702.5), Heart (RPKM 595.0) and 9 other tissues See more
Orthologs
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Genomic context

See Timp2 in Genome Data Viewer
Location:
10q32.3
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103541199..103590611, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (107338465..107386072, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene cytohesin 1 Neighboring gene ubiquitin specific peptidase 36 Neighboring gene CEP295 N-terminal like Neighboring gene galectin 3 binding protein Neighboring gene calcium activated nucleotidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC105282

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metalloendopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Rap protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
metalloproteinase inhibitor 2
Names
TIMP-2
tissue inhibitor of metalloproteinase 2
tissue inhibitor of metalloproteinases 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021989.3NP_068824.1  metalloproteinase inhibitor 2 precursor

    See identical proteins and their annotated locations for NP_068824.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000220
    UniProtKB/Swiss-Prot
    P30121
    Related
    ENSRNOP00000004290.4, ENSRNOT00000004290.5
    Conserved Domains (1) summary
    cd03585
    Location:27209
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    103541199..103590611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085773.1XP_038941701.1  metalloproteinase inhibitor 2 isoform X1

    Conserved Domains (1) summary
    cd03585
    Location:2166
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...
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