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Vav3 vav guanine nucleotide exchange factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295378, updated on 22-Nov-2020

Summary

Official Symbol
Vav3provided by RGD
Official Full Name
vav guanine nucleotide exchange factor 3provided by RGD
Primary source
RGD:1565941
See related
Ensembl:ENSRNOG00000020485
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565941
Expression
Biased expression in Thymus (RPKM 137.3), Kidney (RPKM 129.5) and 8 other tissues See more
Orthologs

Genomic context

See Vav3 in Genome Data Viewer
Location:
2q41
Exon count:
28
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (212247061..212585818)
106 current Rn_Celera (GCF_000002265.2) 2 AC_000070.1 (189650820..189990562)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (231716228..232053965)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 54 Neighboring gene solute carrier family 25 member 24 Neighboring gene mitochondrial ribosomal protein S17, pseudogene 1 Neighboring gene netrin G1 Neighboring gene protein arginine methyltransferase 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell projection assembly ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
immunological synapse ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
guanine nucleotide exchange factor VAV3
Names
vav 3 guanine nucleotide exchange factor
vav 3 oncogene

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191714.1NP_001178643.1  guanine nucleotide exchange factor VAV3

    Status: PROVISIONAL

    Source sequence(s)
    AABR07012868
    UniProtKB/TrEMBL
    F1LWB1
    Related
    ENSRNOP00000027813.5, ENSRNOT00000027813.6
    Conserved Domains (8) summary
    cd10407
    Location:666768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:514561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:193369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00169
    Location:407502
    PH; PH domain
    pfam11971
    Location:18103
    CAMSAP_CH; CAMSAP CH domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    212247061..212585818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590775.1XP_017446264.1  guanine nucleotide exchange factor VAV3 isoform X1

    Related
    ENSRNOP00000073138.1, ENSRNOT00000077883.1

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    189650820..189990562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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