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Rap1a RAP1A, member of RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 295347, updated on 8-Dec-2022

Summary

Official Symbol
Rap1aprovided by RGD
Official Full Name
RAP1A, member of RAS oncogene familyprovided by RGD
Primary source
RGD:1359694
See related
Ensembl:ENSRNOG00000032463 AllianceGenome:RGD:1359694
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RAP-1A; rap 1A
Summary
Enables GTP binding activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including cellular response to cAMP; liver regeneration; and positive regulation of signal transduction. Located in cytoplasmic vesicle and perinuclear region of cytoplasm. Orthologous to human RAP1A (RAP1A, member of RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 384.6), Spleen (RPKM 296.1) and 9 other tissues See more
Orthologs
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Genomic context

See Rap1a in Genome Data Viewer
Location:
2q34
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (193208631..193286513, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (208193950..208215186, complement)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 20 Neighboring gene inka box actin regulator 2 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene uncharacterized LOC102548822 Neighboring gene uncharacterized LOC108350083 Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene adenosine A3 receptor Neighboring gene SUB1 regulator of transcription, pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93785, MGC94873

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Rap protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Rap protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in Rap protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in Rap protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to cAMP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
 
involved_in cellular response to nerve growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to nerve growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
NOT involved_in microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in nerve growth factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in response to antineoplastic agent IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to carbohydrate IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
 
located_in sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rap-1A
Names
RAS-related protein 1a
ras-related protein Krev-1
NP_001005765.1
XP_038958003.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005765.1NP_001005765.1  ras-related protein Rap-1A

    See identical proteins and their annotated locations for NP_001005765.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083813
    UniProtKB/Swiss-Prot
    P62836
    Related
    ENSRNOP00000040409.2, ENSRNOT00000047836.5
    Conserved Domains (1) summary
    cd04175
    Location:3167
    Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    193208631..193286513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102075.1XP_038958003.1  ras-related protein Rap-1A isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:3144
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases