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Ptgs2 prostaglandin-endoperoxide synthase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29527, updated on 17-Nov-2020

Summary

Official Symbol
Ptgs2provided by RGD
Official Full Name
prostaglandin-endoperoxide synthase 2provided by RGD
Primary source
RGD:620349
See related
Ensembl:ENSRNOG00000002525
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cox2; COX-2
Summary
catalyzes the conversion of arachidonic acid products to prostaglandin; may play a role in response to endotoxic shock; may a role in long term potentiation [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 161.3), Brain (RPKM 53.0) and 4 other tissues See more
Orthologs

Genomic context

See Ptgs2 in Genome Data Viewer
Location:
13q21
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (67351230..67356920)
106 current Rn_Celera (GCF_000002265.2) 13 AC_000081.1 (62129439..62135131)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (72315959..72324483)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group IVA Neighboring gene uncharacterized LOC100911717 Neighboring gene hypothetical LOC100364450 Neighboring gene uncharacterized LOC108352549

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-endoperoxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
prostaglandin-endoperoxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to ATP IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to UV IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to non-ionic osmotic stress ISO
Inferred from Sequence Orthology
more info
 
cyclooxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
cyclooxygenase pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
decidualization ISO
Inferred from Sequence Orthology
more info
 
embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo implantation ISO
Inferred from Sequence Orthology
more info
 
hair cycle IEP
Inferred from Expression Pattern
more info
PubMed 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel diameter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fever generation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fever generation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of platelet-derived growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
 
regulation of neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
response to cytokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to fructose IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lithium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with caveola IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prostaglandin G/H synthase 2
Names
PGH synthase 2
PGHS-2
PHS II
cyclooxygenase-2
prostaglandin H2 synthase 2
NP_058928.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017232.3NP_058928.3  prostaglandin G/H synthase 2 precursor

    See identical proteins and their annotated locations for NP_058928.3

    Status: PROVISIONAL

    Source sequence(s)
    U04300
    UniProtKB/Swiss-Prot
    P35355
    Related
    ENSRNOP00000003567.2, ENSRNOT00000003567.4
    Conserved Domains (2) summary
    cd09816
    Location:75562
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    pfam00008
    Location:2153
    EGF; EGF-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    67351230..67356920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    62129439..62135131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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