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Gabpb2 GA binding protein transcription factor subunit beta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295263, updated on 7-Sep-2023

Summary

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Official Symbol
Gabpb2provided by RGD
Official Full Name
GA binding protein transcription factor subunit beta 2provided by RGD
Primary source
RGD:1565234
See related
Ensembl:ENSRNOG00000021105 AllianceGenome:RGD:1565234
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565234
Summary
Predicted to enable identical protein binding activity and transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human GABPB2 (GA binding protein transcription factor subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 100.2), Thymus (RPKM 91.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gabpb2 in Genome Data Viewer
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182755304..182795368, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196357030..196392514, complement)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene LysM domain containing 1 Neighboring gene TNF alpha induced protein 8 like 2 Neighboring gene uncharacterized LOC120100877 Neighboring gene semaphorin 6C Neighboring gene MLLT11, transcription factor 7 cofactor Neighboring gene CDC42 small effector 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals. Du K, et al. J Biol Chem, 1998 Dec 25. PMID 9857059
  2. Molecular and genetic characterization of GABP beta. de la Brousse FC, et al. Genes Dev, 1994 Aug 1. PMID 7958862
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GA-binding protein subunit beta-2
Names
GA binding protein transcription factor, beta subunit 2
GA repeat binding protein, beta 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_015227675.2-RS_2023_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    182755304..182795368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232936.3 → XP_006232998.1  GA-binding protein subunit beta-2

    See identical proteins and their annotated locations for XP_006232998.1

    UniProtKB/TrEMBL
    D3ZSD3
    Conserved Domains (4) summary
    cd00204
    Location:34 → 156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:42 → 132
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]

  2. XM_227439.8 → XP_227439.6  GA-binding protein subunit beta-2

    See identical proteins and their annotated locations for XP_227439.6

    UniProtKB/TrEMBL
    D3ZSD3
    Related
    ENSRNOP00000028661.5, ENSRNOT00000028661.8
    Conserved Domains (4) summary
    cd00204
    Location:34 → 156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:42 → 132
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]

RNA

  1. XR_005501120.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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