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Pitpna phosphatidylinositol transfer protein, alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 29525, updated on 22-Nov-2020

Summary

Official Symbol
Pitpnaprovided by RGD
Official Full Name
phosphatidylinositol transfer protein, alphaprovided by RGD
Primary source
RGD:61885
See related
Ensembl:ENSRNOG00000003846
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pitpn
Summary
catalyzes the transfer of phosphatidylinositol (PtdIns) between membranes [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 485.3), Heart (RPKM 323.9) and 9 other tissues See more
Orthologs

Genomic context

See Pitpna in Genome Data Viewer
Location:
10q24
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63731767..63772049)
106 current Rn_Celera (GCF_000002265.2) 10 AC_000078.1 (59458996..59498755)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (64232947..64273229, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene Rab interacting lysosomal protein Neighboring gene scavenger receptor class F, member 1 Neighboring gene solute carrier family 43 member 2 Neighboring gene glutathione peroxidase 4, pseudogene 2 Neighboring gene inositol polyphosphate-5-phosphatase K Neighboring gene myosin 1C

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
fatty-acyl-CoA binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine transfer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylcholine transfer activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine transporter activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine transporter activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol transfer activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol transfer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol transfer activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol transfer activity TAS
Traceable Author Statement
more info
PubMed 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
stearic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
 
phospholipid transport IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid transport IEA
Inferred from Electronic Annotation
more info
 
phospholipid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
phosphatidylinositol transfer protein alpha isoform
Names
PI-TP-alpha
ptdIns transfer protein alpha
ptdInsTP alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017231.1NP_058927.1  phosphatidylinositol transfer protein alpha isoform

    See identical proteins and their annotated locations for NP_058927.1

    Status: PROVISIONAL

    Source sequence(s)
    M25758
    UniProtKB/Swiss-Prot
    P16446
    Related
    ENSRNOP00000072145.1, ENSRNOT00000090554.1
    Conserved Domains (1) summary
    cd08888
    Location:3260
    SRPBCC_PITPNA-B_like; Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    63731767..63772049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    59458996..59498755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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