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Pde3b phosphodiesterase 3B [ Rattus norvegicus (Norway rat) ]

Gene ID: 29516, updated on 6-Jul-2026
Official Symbol
Pde3bprovided by RGD
Official Full Name
phosphodiesterase 3Bprovided by RGD
Primary source
RGD:61943
See related
Ensembl:ENSRNOG00000011417 AllianceGenome:RGD:61943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RcGIPl; CGI PDE
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and phosphoprotein binding activity. Involved in negative regulation of cAMP/PKA signal transduction and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Predicted to be part of guanyl-nucleotide exchange factor complex. Orthologous to human PDE3B (phosphodiesterase 3B). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Liver (RPKM 197.1), Thymus (RPKM 178.1) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Pde3b in Genome Data Viewer
Location:
1q34
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (178041207..178204503)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (168606762..168770078)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485165 Neighboring gene ATP synthase membrane subunit j, pseudogene 1 Neighboring gene proteasome 20S subunit alpha 1 Neighboring gene uncharacterized LOC134483775 Neighboring gene ubiquitin-like protein FUBI-like Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1 Neighboring gene calcitonin-related polypeptide alpha Neighboring gene calcitonin-related polypeptide, beta

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase. Taira M, et al. J Biol Chem, 1993 Sep 5. PMID 8395509
  2. Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin. Härndahl L, et al. J Biol Chem, 2002 Oct 4. PMID 12169692
  3. The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury. Choi WI, et al. BMC Infect Dis, 2009 Jun 1. PMID 19486524, Free PMC Article
  4. Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes. Zmuda-Trzebiatowska E, et al. Cell Signal, 2006 Mar. PMID 15961276
  5. A newly identified 50 kDa protein, which is associated with phosphodiesterase 3B, is phosphorylated by insulin in rat adipocytes. Onuma H, et al. Biochem Biophys Res Commun, 2005 Nov 25. PMID 16225849

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diosgenin reduces phosphodiesterase 3B (PDE3B) through AMP-activated protein kinase/ mechanistic target of rapamycin (AMPK/mTOR) signaling pathway to ameliorate streptozotocin-induced pancreatic beta-cell apoptosis and dysfunction.
    Title: Diosgenin reduces phosphodiesterase 3B (PDE3B) through AMP-activated protein kinase/ mechanistic target of rapamycin (AMPK/mTOR) signaling pathway to ameliorate streptozotocin-induced pancreatic β-cell apoptosis and dysfunction.
  2. C-peptide has the potential to act, conditionally, as an antilipolytic hormone by activating phosphodiesterase-3B.
    Title: Proinsulin C-peptide inhibits lipolysis in diabetic rat adipose tissue through phosphodiestrase-3B enzyme.
  3. PI3K but not Akt is an upstream regulator of the PDE3B pathway of leptin signalling in the rat hypothalamus.
    Title: Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus.
  4. Data demonstrate that AG/UAG attenuation of ISO-induced lipolysis involves PI3Kgamma/AKT and PDE3B.
    Title: Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.
  5. PDE3B is activated in response to agents relevant for beta-cell function and activation is linked to increased as well as decreased phosphorylation of the enzyme
    Title: Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.
  6. PDE3 inhibition reverses leptin-induced stimulation of proopiomelanocortin and neurotensin gene expression; the PDE3B pathway plays an important role in mediating leptin action in the hypothalamus
    Title: A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus.
  7. Increased expression of PDE3B along with decreased cAMP in the exdotoxemic kidneys were associated with reduced renal function, alteration of renal tubular cell morphology, and increased iNOS expression.
    Title: The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury.
  8. PDE3B, a key enzyme in insulin signalling, appears to be associated with caveolae in adipocytes and this localization seems to be functionally important.
    Title: Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes.
  9. plays an important role in the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin
    Title: Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin.
  10. data suggest that PDE3B, but not PDE4, contributes to the regulation of insulin-induced glucose uptake, GLUT-4 translocation, and lipogenesis presumably by regulation of a cAMP/Epac signalling mechanisms
    Title: Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity EXP
Inferred from Experiment
more info
 PubMed 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase B binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocrine pancreas development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cAMP/PKA signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cAMP/PKA signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cAMP/PKA signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Names
CGI-PDE B
CGIPDE1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
cyclic GMP-inhibited phosphodiesterase B
phosphodiesterase 3B, cGMP-inhibited
NP_058925.2
XP_038965381.1
XP_038965386.1
XP_038965388.1
XP_038965391.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017229.2 → NP_058925.2  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q63085
    UniProtKB/TrEMBL
    A0ABK0LDR6
    Related
    ENSRNOP00000101474.1, ENSRNOT00000157387.1
    Conserved Domains (2) summary
    pfam00233
    Location:718 → 992
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam11992
    Location:145 → 264
    DUF3488; Domain of unknown function (DUF3488)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    178041207..178204503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109460.2 → XP_038965388.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X3

  2. XM_039109453.2 → XP_038965381.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1

  3. XM_039109463.2 → XP_038965391.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X4

  4. XM_039109458.2 → XP_038965386.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X2

    Conserved Domains (1) summary
    pfam00233
    Location:229 → 492
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63085.1 GenPept UniProtKB/Swiss-Prot:Q63085

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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