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Pctp phosphatidylcholine transfer protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 29510, updated on 12-Jan-2022

Summary

Official Symbol
Pctpprovided by RGD
Official Full Name
phosphatidylcholine transfer proteinprovided by RGD
Primary source
RGD:3276
See related
Ensembl:ENSRNOG00000002425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PC-TP; stARD2
Summary
Predicted to enable phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phospholipid transport. Predicted to act upstream of or within cholesterol metabolic process. Predicted to be located in cytosol. Orthologous to human PCTP (phosphatidylcholine transfer protein). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Liver (RPKM 243.0), Testes (RPKM 114.6) and 8 other tissues See more
Orthologs
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Genomic context

See Pctp in Genome Data Viewer
Location:
10q26
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (74808887..74856260, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (77491445..77537268, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547753 Neighboring gene noggin Neighboring gene ankyrin-repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC120095174 Neighboring gene uncharacterized LOC103693415 Neighboring gene transmembrane protein 100 Neighboring gene monocyte to macrophage differentiation-associated

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylcholine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylcholine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylcholine transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylcholine transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylcholine transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipid transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
phosphatidylcholine transfer protein
Names
START domain-containing protein 2
stAR-related lipid transfer protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322798.1NP_001309727.1  phosphatidylcholine transfer protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    FN798834, JACYVU010000220
    Related
    ENSRNOP00000093865.1, ENSRNOT00000095165.1
    Conserved Domains (1) summary
    cl14643
    Location:198
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  2. NM_017225.3NP_058921.1  phosphatidylcholine transfer protein isoform 1

    See identical proteins and their annotated locations for NP_058921.1

    Status: VALIDATED

    Source sequence(s)
    FN798833, JACYVU010000220
    UniProtKB/Swiss-Prot
    P53809
    Related
    ENSRNOP00000003295.1, ENSRNOT00000003295.5
    Conserved Domains (1) summary
    cd08910
    Location:4210
    START_STARD2-like; Lipid-binding START domain of mammalian STARD2 and related proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    74808887..74856260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085771.1XP_038941699.1  phosphatidylcholine transfer protein isoform X2

    Conserved Domains (1) summary
    cl14643
    Location:1138
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  2. XM_039085770.1XP_038941698.1  phosphatidylcholine transfer protein isoform X2

    Conserved Domains (1) summary
    cl14643
    Location:1138
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  3. XM_008767983.2XP_008766205.1  phosphatidylcholine transfer protein isoform X2

    See identical proteins and their annotated locations for XP_008766205.1

    Conserved Domains (1) summary
    cl14643
    Location:1138
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  4. XM_008767982.3XP_008766204.1  phosphatidylcholine transfer protein isoform X2

    See identical proteins and their annotated locations for XP_008766204.1

    Conserved Domains (1) summary
    cl14643
    Location:1138
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  5. XM_006247125.3XP_006247187.1  phosphatidylcholine transfer protein isoform X1

    Related
    ENSRNOP00000079674.1, ENSRNOT00000103306.1
    Conserved Domains (1) summary
    cl14643
    Location:4170
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
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