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Slc22a6 solute carrier family 22 member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29509, updated on 4-Jun-2020

Summary

Official Symbol
Slc22a6provided by RGD
Official Full Name
solute carrier family 22 member 6provided by RGD
Primary source
RGD:69338
See related
Ensembl:ENSRNOG00000018215
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Oat1; Paht; Roat1; Orctl1
Summary
multispecific organic anion transporter; involved in anion transport in a proximal tubule in the kidney [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 1961.7) See more
Orthologs

Genomic context

See Slc22a6 in Genome Data Viewer
Location:
1q43
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224824809..224833284)
106 current Rn_Celera (GCF_000002265.2) 1 AC_000069.1 (203036078..203044298)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (231761600..231772550)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S12-like Neighboring gene solute carrier family 22 member 8 Neighboring gene uncharacterized LOC102550957 Neighboring gene cholinergic receptor, muscarinic 1 Neighboring gene solute carrier family 3 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124962

Gene Ontology Provided by RGD

Function Evidence Code Pubs
anion:anion antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
chloride ion binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
inorganic anion exchanger activity ISO
Inferred from Sequence Orthology
more info
 
inorganic anion exchanger activity ISS
Inferred from Sequence or Structural Similarity
more info
 
organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium-independent organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium-independent organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
alpha-ketoglutarate transport ISO
Inferred from Sequence Orthology
more info
 
alpha-ketoglutarate transport ISS
Inferred from Sequence or Structural Similarity
more info
 
anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
anion transport ISO
Inferred from Sequence Orthology
more info
 
inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organic anion transport IDA
Inferred from Direct Assay
more info
PubMed 
organic anion transport ISO
Inferred from Sequence Orthology
more info
 
renal tubular secretion ISO
Inferred from Sequence Orthology
more info
 
renal tubular secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
response to methotrexate IEP
Inferred from Expression Pattern
more info
PubMed 
sodium-independent organic anion transport IDA
Inferred from Direct Assay
more info
PubMed 
sodium-independent organic anion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
solute carrier family 22 member 6
Names
organic anion transporter 1
organic cationic transporter-like 1
rROAT1
renal organic anion transporter 1
solute carrier family 22 (organic anion transporter), member 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017224.2NP_058920.1  solute carrier family 22 member 6

    See identical proteins and their annotated locations for NP_058920.1

    Status: PROVISIONAL

    Source sequence(s)
    BC104692
    UniProtKB/Swiss-Prot
    O35956
    Related
    ENSRNOP00000024756.2, ENSRNOT00000024757.4
    Conserved Domains (2) summary
    cd06174
    Location:135505
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11515
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    224824809..224833284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230978.2XP_006231040.1  solute carrier family 22 member 6 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:135456
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11471
    2A0119; cation transport protein

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    203036078..203044298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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