Format

Send to:

Choose Destination

Slc22a6 solute carrier family 22 member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29509, updated on 22-Aug-2021

Summary

Official Symbol
Slc22a6provided by RGD
Official Full Name
solute carrier family 22 member 6provided by RGD
Primary source
RGD:69338
See related
Ensembl:ENSRNOG00000018215
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Oat1; Paht; Roat1; Orctl1
Summary
multispecific organic anion transporter; involved in anion transport in a proximal tubule in the kidney [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 1961.7) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Slc22a6 in Genome Data Viewer
Location:
1q43
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205522579..205531179)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224824809..224833284)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22, member 25 Neighboring gene 40S ribosomal protein S12-like Neighboring gene uncharacterized LOC102550957 Neighboring gene solute carrier family 22 member 8 Neighboring gene cholinergic receptor, muscarinic 1 Neighboring gene solute carrier family 3 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124962

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in alpha-ketoglutarate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in alpha-ketoglutarate transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within anion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within organic anion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in organic anion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in renal tubular secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in renal tubular secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to methotrexate IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sodium-independent organic anion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium-independent organic anion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
solute carrier family 22 member 6
Names
organic anion transporter 1
organic cationic transporter-like 1
rROAT1
renal organic anion transporter 1
solute carrier family 22 (organic anion transporter), member 6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017224.2NP_058920.1  solute carrier family 22 member 6

    See identical proteins and their annotated locations for NP_058920.1

    Status: PROVISIONAL

    Source sequence(s)
    BC104692
    UniProtKB/Swiss-Prot
    O35956
    Related
    ENSRNOP00000024756.2, ENSRNOT00000024757.4
    Conserved Domains (2) summary
    cd06174
    Location:135505
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11515
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    205522579..205531179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230978.3XP_006231040.1  solute carrier family 22 member 6 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:135456
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11471
    2A0119; cation transport protein
Support Center