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Shh sonic hedgehog signaling molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 29499, updated on 7-May-2019

Summary

Official Symbol
Shhprovided by RGD
Official Full Name
sonic hedgehog signaling moleculeprovided by RGD
Primary source
RGD:3673
See related
Ensembl:ENSRNOG00000006120
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ShhNC
Summary
plays a role in neurogenesis; regulates proliferation of adult hippocampal neural stem cells [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 94.4), Lung (RPKM 38.0) and 1 other tissue See more
Orthologs

Genomic context

See Shh in Genome Data Viewer
Location:
4q11
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (718538..727691, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (711420..720573, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene protein canopy homolog 1-like Neighboring gene RNA binding motif protein 33 Neighboring gene uncharacterized LOC103692014 Neighboring gene uncharacterized LOC108350640 Neighboring gene uncharacterized LOC102546975 Neighboring gene RNA-binding protein 33-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
glycosaminoglycan binding IEA
Inferred from Electronic Annotation
more info
 
glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT hydrolase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
laminin-1 binding IEA
Inferred from Electronic Annotation
more info
 
laminin-1 binding ISO
Inferred from Sequence Orthology
more info
PubMed 
laminin-1 binding ISS
Inferred from Sequence or Structural Similarity
more info
 
patched binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
patched binding IEA
Inferred from Electronic Annotation
more info
 
patched binding ISO
Inferred from Sequence Orthology
more info
PubMed 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Bergmann glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Bergmann glial cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment ISO
Inferred from Sequence Orthology
more info
PubMed 
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
PubMed 
T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
 
anatomical structure development ISO
Inferred from Sequence Orthology
more info
PubMed 
anatomical structure formation involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
androgen metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
androgen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
animal organ formation IEA
Inferred from Electronic Annotation
more info
 
animal organ formation ISO
Inferred from Sequence Orthology
more info
PubMed 
anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
PubMed 
apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
artery development IEA
Inferred from Electronic Annotation
more info
 
artery development ISO
Inferred from Sequence Orthology
more info
PubMed 
axon guidance IEA
Inferred from Electronic Annotation
more info
 
axon guidance ISO
Inferred from Sequence Orthology
more info
PubMed 
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
blood coagulation ISO
Inferred from Sequence Orthology
more info
PubMed 
branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
branching involved in blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in prostate gland morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
PubMed 
branching morphogenesis of an epithelial tube ISS
Inferred from Sequence or Structural Similarity
more info
 
bud outgrowth involved in lung branching IEA
Inferred from Electronic Annotation
more info
 
bud outgrowth involved in lung branching ISO
Inferred from Sequence Orthology
more info
PubMed 
camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
camera-type eye development ISO
Inferred from Sequence Orthology
more info
PubMed 
canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
cell development ISO
Inferred from Sequence Orthology
more info
PubMed 
cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate commitment ISO
Inferred from Sequence Orthology
more info
PubMed 
cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell fate specification IEA
Inferred from Electronic Annotation
more info
 
cell fate specification ISO
Inferred from Sequence Orthology
more info
PubMed 
cell fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
cell proliferation in external granule layer ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to lithium ion ISO
Inferred from Sequence Orthology
more info
PubMed 
central nervous system development ISO
Inferred from Sequence Orthology
more info
PubMed 
central nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellar granule cell precursor proliferation IEA
Inferred from Electronic Annotation
more info
 
cerebellar granule cell precursor proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
cerebellar granule cell precursor proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
commissural neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of left/right asymmetry in lateral mesoderm IEA
Inferred from Electronic Annotation
more info
 
determination of left/right asymmetry in lateral mesoderm ISO
Inferred from Sequence Orthology
more info
PubMed 
determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
PubMed 
developmental growth ISO
Inferred from Sequence Orthology
more info
PubMed 
digestive tract mesoderm development IDA
Inferred from Direct Assay
more info
PubMed 
digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
dorsal/ventral neural tube patterning IEA
Inferred from Electronic Annotation
more info
 
dorsal/ventral neural tube patterning ISO
Inferred from Sequence Orthology
more info
PubMed 
dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
PubMed 
dorsal/ventral pattern formation ISS
Inferred from Sequence or Structural Similarity
more info
 
ectoderm development IEA
Inferred from Electronic Annotation
more info
 
ectoderm development ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic digit morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic foregut morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic foregut morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic limb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic organ development ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic skeletal system development IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
endocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
epithelial cell proliferation involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epithelial cell proliferation involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
epithelial tube branching involved in lung morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
epithelial tube branching involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
epithelial-mesenchymal cell signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
epithelial-mesenchymal signaling involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
PubMed 
forebrain development ISO
Inferred from Sequence Orthology
more info
PubMed 
forebrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
forebrain regionalization ISO
Inferred from Sequence Orthology
more info
PubMed 
formation of anatomical boundary IEA
Inferred from Electronic Annotation
more info
 
formation of anatomical boundary ISO
Inferred from Sequence Orthology
more info
PubMed 
fungiform papilla development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fungiform papilla formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fungiform papilla morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle development ISO
Inferred from Sequence Orthology
more info
PubMed 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
heart development ISO
Inferred from Sequence Orthology
more info
PubMed 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart looping IEA
Inferred from Electronic Annotation
more info
 
heart looping ISO
Inferred from Sequence Orthology
more info
PubMed 
hindbrain development ISO
Inferred from Sequence Orthology
more info
PubMed 
hindbrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
hindgut morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hindgut morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
inner ear development ISO
Inferred from Sequence Orthology
more info
PubMed 
intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
 
intermediate filament organization IEA
Inferred from Electronic Annotation
more info
 
intermediate filament organization ISO
Inferred from Sequence Orthology
more info
PubMed 
kidney development ISO
Inferred from Sequence Orthology
more info
PubMed 
left lung development IEA
Inferred from Electronic Annotation
more info
 
left lung development ISO
Inferred from Sequence Orthology
more info
PubMed 
limb bud formation IEA
Inferred from Electronic Annotation
more info
 
limb bud formation ISO
Inferred from Sequence Orthology
more info
PubMed 
limb development ISO
Inferred from Sequence Orthology
more info
PubMed 
liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
lung development ISO
Inferred from Sequence Orthology
more info
PubMed 
lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung epithelium development IEA
Inferred from Electronic Annotation
more info
 
lung epithelium development ISO
Inferred from Sequence Orthology
more info
PubMed 
lung lobe morphogenesis IEA
Inferred from Electronic Annotation
more info
 
lung lobe morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
lung morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
lung-associated mesenchyme development IEA
Inferred from Electronic Annotation
more info
 
lung-associated mesenchyme development ISO
Inferred from Sequence Orthology
more info
PubMed 
lymphoid progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lymphoid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
lymphoid progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
male genitalia development IEA
Inferred from Electronic Annotation
more info
 
male genitalia development ISO
Inferred from Sequence Orthology
more info
PubMed 
male genitalia development ISS
Inferred from Sequence or Structural Similarity
more info
 
male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
mesenchymal cell proliferation involved in lung development IEA
Inferred from Electronic Annotation
more info
 
mesenchymal cell proliferation involved in lung development ISO
Inferred from Sequence Orthology
more info
PubMed 
mesenchymal smoothened signaling pathway involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
mesenchymal smoothened signaling pathway involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
metanephric mesenchymal cell proliferation involved in metanephros development IEA
Inferred from Electronic Annotation
more info
 
metanephric mesenchymal cell proliferation involved in metanephros development ISO
Inferred from Sequence Orthology
more info
PubMed 
metanephric mesenchymal cell proliferation involved in metanephros development ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephros development ISO
Inferred from Sequence Orthology
more info
PubMed 
metanephros development ISS
Inferred from Sequence or Structural Similarity
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
midbrain development ISO
Inferred from Sequence Orthology
more info
PubMed 
midbrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
myoblast differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
myotube differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cholesterol efflux IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of dopaminergic neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of kidney smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of kidney smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of kidney smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mesenchymal cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mesenchymal cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription elongation from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription elongation from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of ureter smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ureter smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of ureter smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
negative thymic T cell selection ISO
Inferred from Sequence Orthology
more info
PubMed 
negative thymic T cell selection ISS
Inferred from Sequence or Structural Similarity
more info
 
neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
neural crest cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
neural tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
neuroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron fate commitment IEA
Inferred from Electronic Annotation
more info
 
neuron fate commitment ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
odontogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
PubMed 
oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
PubMed 
oligodendrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
osteoblast development IEA
Inferred from Electronic Annotation
more info
 
osteoblast development ISO
Inferred from Sequence Orthology
more info
PubMed 
pancreas development IEA
Inferred from Electronic Annotation
more info
 
pancreas development ISO
Inferred from Sequence Orthology
more info
PubMed 
pattern specification process ISO
Inferred from Sequence Orthology
more info
PubMed 
pattern specification process ISS
Inferred from Sequence or Structural Similarity
more info
 
polarity specification of anterior/posterior axis IEA
Inferred from Electronic Annotation
more info
 
polarity specification of anterior/posterior axis ISO
Inferred from Sequence Orthology
more info
PubMed 
polarity specification of anterior/posterior axis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell division ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cerebellar granule cell precursor proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of hh target transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hh target transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of immature T cell proliferation in thymus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of immature T cell proliferation in thymus ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of immature T cell proliferation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of kidney smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of kidney smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of kidney smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mesenchymal cell proliferation involved in ureter development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mesenchymal cell proliferation involved in ureter development ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mesenchymal cell proliferation involved in ureter development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neurotrophin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of oligodendrocyte progenitor proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of penile erection IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of photoreceptor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of sclerotome development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sclerotome development ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of skeletal muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of striated muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ureter smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ureter smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ureter smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
positive thymic T cell selection ISO
Inferred from Sequence Orthology
more info
PubMed 
positive thymic T cell selection ISS
Inferred from Sequence or Structural Similarity
more info
 
primary prostatic bud elongation IEA
Inferred from Electronic Annotation
more info
 
primary prostatic bud elongation ISO
Inferred from Sequence Orthology
more info
PubMed 
prostate epithelial cord elongation IEA
Inferred from Electronic Annotation
more info
 
prostate epithelial cord elongation ISO
Inferred from Sequence Orthology
more info
PubMed 
prostate gland development IEP
Inferred from Expression Pattern
more info
PubMed 
prostate gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
prostate gland development ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT prostatic bud formation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of epithelial cell proliferation involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of mesenchymal cell proliferation involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
regulation of mesenchymal cell proliferation involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of odontogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of odontogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of prostatic bud formation IEA
Inferred from Electronic Annotation
more info
 
regulation of prostatic bud formation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
renal system development ISO
Inferred from Sequence Orthology
more info
PubMed 
respiratory tube development ISO
Inferred from Sequence Orthology
more info
PubMed 
response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
right lung development IEA
Inferred from Electronic Annotation
more info
 
right lung development ISO
Inferred from Sequence Orthology
more info
PubMed 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
roof of mouth development ISO
Inferred from Sequence Orthology
more info
PubMed 
salivary gland cavitation IEA
Inferred from Electronic Annotation
more info
 
salivary gland cavitation ISO
Inferred from Sequence Orthology
more info
PubMed 
skin development ISO
Inferred from Sequence Orthology
more info
PubMed 
smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
somite development IEA
Inferred from Electronic Annotation
more info
 
somite development ISO
Inferred from Sequence Orthology
more info
PubMed 
spinal cord dorsal/ventral patterning IDA
Inferred from Direct Assay
more info
PubMed 
spinal cord dorsal/ventral patterning IEA
Inferred from Electronic Annotation
more info
 
spinal cord dorsal/ventral patterning ISO
Inferred from Sequence Orthology
more info
PubMed 
spinal cord motor neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
spinal cord motor neuron differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
stem cell development ISO
Inferred from Sequence Orthology
more info
PubMed 
stem cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
striated muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
striated muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
PubMed 
telencephalon regionalization IEA
Inferred from Electronic Annotation
more info
 
telencephalon regionalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
telencephalon regionalization ISO
Inferred from Sequence Orthology
more info
PubMed 
thalamus development IEA
Inferred from Electronic Annotation
more info
 
thalamus development ISO
Inferred from Sequence Orthology
more info
PubMed 
thymus development IEA
Inferred from Electronic Annotation
more info
 
thymus development ISO
Inferred from Sequence Orthology
more info
PubMed 
thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
thyroid gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
tongue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
tongue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
trachea development ISO
Inferred from Sequence Orthology
more info
PubMed 
trachea morphogenesis IEA
Inferred from Electronic Annotation
more info
 
trachea morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
tracheoesophageal septum formation IEA
Inferred from Electronic Annotation
more info
 
tracheoesophageal septum formation ISO
Inferred from Sequence Orthology
more info
PubMed 
vasculature development ISO
Inferred from Sequence Orthology
more info
PubMed 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ventral spinal cord interneuron specification IDA
Inferred from Direct Assay
more info
PubMed 
zona limitans intrathalamica formation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sonic hedgehog protein
Names
shh unprocessed N-terminal signaling and C-terminal autoprocessing domains
sonic hedgehog homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017221.1NP_058917.1  sonic hedgehog protein precursor

    Status: PROVISIONAL

    Source sequence(s)
    L27340
    UniProtKB/Swiss-Prot
    Q63673
    Related
    ENSRNOP00000008497.1, ENSRNOT00000008497.2
    Conserved Domains (3) summary
    cd00081
    Location:199349
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    pfam01079
    Location:188423
    Hint; Hint module
    pfam01085
    Location:40185
    HH_signal; Hedgehog amino-terminal signalling domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    718538..727691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    3316537..3325690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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