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Erbb3 erb-b2 receptor tyrosine kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29496, updated on 18-Apr-2019

Summary

Official Symbol
Erbb3provided by RGD
Official Full Name
erb-b2 receptor tyrosine kinase 3provided by RGD
Primary source
RGD:69323
See related
Ensembl:ENSRNOG00000004964
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
nuc-ErbB3
Summary
acts as a tyrosine kinase receptor for neuregulin; may play a role in axonal regeneration in response to injury [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 239.0), Liver (RPKM 205.8) and 7 other tissues See more
Orthologs

Genomic context

See Erbb3 in Genome Data Viewer
Location:
7q11
Exon count:
31
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2989202..3010610, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (2962964..2984938, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene ribosomal protein L41 Neighboring gene proliferation-associated 2G4 Neighboring gene ribosomal protein S27a, pseudogene 11 Neighboring gene similar to prefoldin 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
growth factor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
neuregulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuregulin binding IEA
Inferred from Electronic Annotation
more info
 
neuregulin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuregulin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
neuregulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
neuregulin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuregulin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein tyrosine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
Schwann cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Schwann cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
axonogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
cranial nerve development IEA
Inferred from Electronic Annotation
more info
 
cranial nerve development ISO
Inferred from Sequence Orthology
more info
PubMed 
endocardial cushion development IEA
Inferred from Electronic Annotation
more info
 
endocardial cushion development ISO
Inferred from Sequence Orthology
more info
PubMed 
epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
PubMed 
mammary gland involution IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
odontogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system development ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cardiac muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
skeletal muscle tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
tongue development IEP
Inferred from Expression Pattern
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
receptor tyrosine-protein kinase erbB-3
Names
avian erythroblastosis oncogene B 3
c-erbB-3
c-erbB3
proto-oncogene-like protein c-ErbB-3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
NP_058914.2
XP_017450189.1
XP_017450190.1
XP_017450191.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017218.3NP_058914.2  receptor tyrosine-protein kinase erbB-3 precursor

    See identical proteins and their annotated locations for NP_058914.2

    Status: PROVISIONAL

    Source sequence(s)
    U29339
    UniProtKB/Swiss-Prot
    Q62799
    Related
    ENSRNOP00000006796.3, ENSRNOT00000006796.4
    Conserved Domains (8) summary
    cd12095
    Location:638674
    TM_ErbB3; Transmembrane domain of ErbB3, a Protein Tyrosine Kinase
    smart00261
    Location:548592
    FU; Furin-like repeats
    cd00064
    Location:226266
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179329
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353474
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:707963
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:499630
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:699977
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    2989202..3010610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594700.1XP_017450189.1  receptor tyrosine-protein kinase erbB-3 isoform X1

    UniProtKB/TrEMBL
    G3V6N1
    Conserved Domains (8) summary
    cd12095
    Location:638674
    TM_ErbB3; Transmembrane domain of ErbB3, a Protein Tyrosine Kinase
    smart00261
    Location:548592
    FU; Furin-like repeats
    cd00064
    Location:226266
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179329
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353474
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:707963
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:499630
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:699977
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017594701.1XP_017450190.1  receptor tyrosine-protein kinase erbB-3 isoform X2

  3. XM_017594702.1XP_017450191.1  receptor tyrosine-protein kinase erbB-3 isoform X3

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    866587..885873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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