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Dlg4 discs large MAGUK scaffold protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29495, updated on 19-Apr-2019

Summary

Official Symbol
Dlg4provided by RGD
Official Full Name
discs large MAGUK scaffold protein 4provided by RGD
Primary source
RGD:68424
See related
Ensembl:ENSRNOG00000018526
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dlgh4; PSD95; Sap90
Summary
a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses; may be involved in guanine nucleotide-mediated signal transduction pathway [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Brain (RPKM 195.0), Adrenal (RPKM 29.1) and 7 other tissues See more
Orthologs

Genomic context

See Dlg4 in Genome Data Viewer
Location:
10q24
Exon count:
24
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56625845..56655543)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (56369703..56400662)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 2 Neighboring gene acyl-CoA dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene uncharacterized LOC102546779 Neighboring gene asialoglycoprotein receptor 1 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
D1 dopamine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
P2Y1 nucleotide receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
acetylcholine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-1 adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-2 adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
immunoglobulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
ionotropic glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
kinase binding IEA
Inferred from Electronic Annotation
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
neuroligin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
scaffold protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of postsynaptic density IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
AMPA glutamate receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to potassium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to potassium ion ISO
Inferred from Sequence Orthology
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
dendritic spine organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization ISO
Inferred from Sequence Orthology
more info
PubMed 
establishment of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
locomotory exploration behavior IEA
Inferred from Electronic Annotation
more info
 
locomotory exploration behavior ISO
Inferred from Sequence Orthology
more info
PubMed 
locomotory exploration behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
maintenance of postsynaptic density structure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
PubMed 
neuromuscular process controlling balance ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal ion channel clustering TAS
Traceable Author Statement
more info
PubMed 
neurotransmitter receptor localization to postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection arborization IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic neurotransmitter receptor diffusion trapping IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor localization to synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of NMDA receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of NMDA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of grooming behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of grooming behavior ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of grooming behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of long-term neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
social behavior IEA
Inferred from Electronic Annotation
more info
 
social behavior ISO
Inferred from Sequence Orthology
more info
PubMed 
social behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle maturation IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle maturation ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic vesicle maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
vocalization behavior IEA
Inferred from Electronic Annotation
more info
 
vocalization behavior ISO
Inferred from Sequence Orthology
more info
PubMed 
vocalization behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
AMPA glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
 
AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
anchored component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
PubMed 
cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cerebellar mossy fiber IEA
Inferred from Electronic Annotation
more info
 
cerebellar mossy fiber ISO
Inferred from Sequence Orthology
more info
PubMed 
cortical cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
PubMed 
dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
PubMed 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
excitatory synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with ionotropic glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with ionotropic glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with ionotropic glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
juxtaparanode region of axon IEA
Inferred from Electronic Annotation
more info
 
juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection terminus IEA
Inferred from Electronic Annotation
more info
 
neuron projection terminus ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron projection terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron spine ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron spine ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynapse ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
disks large homolog 4
Names
PSD-95
SAP-90
discs, large homolog 4
postsynaptic density protein 95
synapse-associated protein 90
synapse-associated protein SAP90

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019621.1NP_062567.1  disks large homolog 4

    See identical proteins and their annotated locations for NP_062567.1

    Status: PROVISIONAL

    Source sequence(s)
    M96853
    UniProtKB/Swiss-Prot
    P31016
    Related
    ENSRNOP00000059045.2, ENSRNOT00000068493.2
    Conserved Domains (7) summary
    cd12030
    Location:430495
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00072
    Location:544710
    GuKc; Guanylate kinase homologues
    smart00228
    Location:310394
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:65149
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:533711
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245312
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:1064
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    56625845..56655543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246684.3XP_006246746.1  disks large homolog 4 isoform X2

    Conserved Domains (8) summary
    cd12030
    Location:475540
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00072
    Location:589755
    GuKc; Guanylate kinase homologues
    smart00228
    Location:355439
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:110194
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:578756
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:290357
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:59109
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cl02672
    Location:3156
    L27; L27 domain
  2. XM_008767809.2XP_008766031.2  disks large homolog 4 isoform X1

    Conserved Domains (6) summary
    cd12030
    Location:370435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00072
    Location:484650
    GuKc; Guanylate kinase homologues
    smart00228
    Location:250334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:589
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185252
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  3. XM_006246687.3XP_006246749.1  disks large homolog 4 isoform X3

    Conserved Domains (7) summary
    cd12030
    Location:427492
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00072
    Location:541707
    GuKc; Guanylate kinase homologues
    smart00228
    Location:307391
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:62146
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:530708
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:242309
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:1061
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  4. XM_017597176.1XP_017452665.1  disks large homolog 4 isoform X1

    Conserved Domains (6) summary
    cd12030
    Location:370435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00072
    Location:484650
    GuKc; Guanylate kinase homologues
    smart00228
    Location:250334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:589
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185252
    PDZ_assoc; PDZ-associated domain of NMDA receptors

RNA

  1. XR_357666.3 RNA Sequence

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    53894685..53920691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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