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GSTM5 glutathione S-transferase mu 5 [ Homo sapiens (human) ]

Gene ID: 2949, updated on 7-Jun-2020

Summary

Official Symbol
GSTM5provided by HGNC
Official Full Name
glutathione S-transferase mu 5provided by HGNC
Primary source
HGNC:HGNC:4637
See related
Ensembl:ENSG00000134201 MIM:138385
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTM5; GSTM5-5
Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]
Expression
Biased expression in ovary (RPKM 81.4), gall bladder (RPKM 13.9) and 9 other tissues See more
Orthologs

Genomic context

See GSTM5 in Genome Data Viewer
Location:
1p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (109711751..109718268)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110254406..110260890)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 2 Neighboring gene glutathione S-transferase mu 1 Neighboring gene glutathione S-transferase mu 3 Neighboring gene EPS8 like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
glutathione S-transferase Mu 5
Names
GST class-mu 5
S-(hydroxyalkyl)glutathione lyase M5
epididymis secretory sperm binding protein
glutathione S-alkyltransferase M5
glutathione S-aralkyltransferase M5
glutathione S-aryltransferase M5
glutathione S-transferase M5
NP_000842.2
XP_005270841.1
XP_005270842.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000851.4NP_000842.2  glutathione S-transferase Mu 5

    See identical proteins and their annotated locations for NP_000842.2

    Status: REVIEWED

    Source sequence(s)
    AC000032, BC058881, BX281326, DB089682
    Consensus CDS
    CCDS811.1
    UniProtKB/Swiss-Prot
    P46439
    UniProtKB/TrEMBL
    Q5T8R2
    Related
    ENSP00000256593.3, ENST00000256593.8
    Conserved Domains (2) summary
    cd03209
    Location:92212
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    109711751..109718268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270784.4XP_005270841.1  glutathione S-transferase Mu 5 isoform X1

    See identical proteins and their annotated locations for XP_005270841.1

    UniProtKB/Swiss-Prot
    P46439
    UniProtKB/TrEMBL
    Q5T8R2
    Related
    ENSP00000496849.1, ENST00000647711.1
    Conserved Domains (2) summary
    cd03209
    Location:92212
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. XM_005270785.4XP_005270842.1  glutathione S-transferase Mu 5 isoform X2

    Conserved Domains (1) summary
    cl02776
    Location:1108
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
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