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Slc1a3 solute carrier family 1 member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29483, updated on 22-May-2022

Summary

Official Symbol
Slc1a3provided by RGD
Official Full Name
solute carrier family 1 member 3provided by RGD
Primary source
RGD:3698
See related
Ensembl:ENSRNOG00000016163 AllianceGenome:RGD:3698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
EAAT1; GLAST; GluT-1; GLAST-1
Summary
Enables high-affinity glutamate transmembrane transporter activity. Involved in L-aspartate import across plasma membrane; L-glutamate import across plasma membrane; and malate-aspartate shuttle. Acts upstream of or within L-glutamate transmembrane transport and response to inorganic substance. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and neuronal cell body. Is integral component of plasma membrane. Part of membrane protein complex. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 1122.4), Adrenal (RPKM 101.1) and 3 other tissues See more
Orthologs
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Genomic context

See Slc1a3 in Genome Data Viewer
Location:
2q16
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (57755495..57830605, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (57860881..57935363, complement)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene high-mobility group nucleosomal binding domain 2-like Neighboring gene uncharacterized LOC103691481 Neighboring gene uncharacterized LOC108349962 Neighboring gene RAN binding protein 3-like Neighboring gene ribosomal protein S2, pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-glutamate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables L-glutamate transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables acidic amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables acidic amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate binding IEA
Inferred from Electronic Annotation
more info
 
enables glutamate binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate:sodium symporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glutamate:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables high-affinity L-glutamate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables high-affinity L-glutamate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables high-affinity L-glutamate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables high-affinity L-glutamate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables neutral amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables organic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in D-aspartate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in D-aspartate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in D-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in D-aspartate import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-aspartate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-aspartate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in L-aspartate import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-aspartate import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within L-glutamate import ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate import ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-glutamate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in L-glutamate import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-glutamate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in acidic amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in auditory behavior IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within auditory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in cell morphogenesis involved in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cocaine IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cranial nerve development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cranial nerve development ISO
Inferred from Sequence Orthology
more info
 
involved_in dicarboxylic acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in gamma-aminobutyric acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gamma-aminobutyric acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in malate-aspartate shuttle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter transport TAS
Traceable Author Statement
more info
PubMed 
involved_in neutral amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to inorganic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to light stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of membrane protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
excitatory amino acid transporter 1
Names
glial glutamate transporter
glutamate transporter
glutamate/aspartate transporter
sodium-dependent glutamate/aspartate transporter 1
solute carrier family 1 (glial high affinity glutamate transporter), member 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289941.1NP_001276870.1  excitatory amino acid transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_001276870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Glast1a, PMID:11086157) lacks an alternate in-frame exon in the 5' coding region, compared to variant Glast. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AF265360, FM094687, FQ082713, S59158
    UniProtKB/Swiss-Prot
    P24942
    UniProtKB/TrEMBL
    A0A0G2JSU1
    Related
    ENSRNOP00000036554.4, ENSRNOT00000035821.6
    Conserved Domains (1) summary
    pfam00375
    Location:45451
    SDF; Sodium:dicarboxylate symporter family
  2. NM_001289942.1NP_001276871.1  excitatory amino acid transporter 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Glast1b) lacks an alternate in-frame exon in the 3' coding region, compared to variant Glast. The encoded protein (isoform 3) is shorter, compared to isoform 1.
    Source sequence(s)
    AF265360, FM094687, FQ082713, FQ097869, S59158
    UniProtKB/Swiss-Prot
    P24942
    UniProtKB/TrEMBL
    A0A0G2KAS7
    Related
    ENSRNOP00000075509.1, ENSRNOT00000085599.2
    Conserved Domains (1) summary
    pfam00375
    Location:50452
    SDF; Sodium:dicarboxylate symporter family
  3. NM_001289943.1NP_001276872.1  excitatory amino acid transporter 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Glast1c, PMID:22026960) lacks two alternate in-frame exons in the coding region, compared to variant Glast. The encoded protein (isoform 4) is shorter, compared to isoform 1.
    Source sequence(s)
    AF265360, FM094687, FQ082713, FQ097869, S59158
    UniProtKB/Swiss-Prot
    P24942
    UniProtKB/TrEMBL
    A0A0G2K611
    Related
    ENSRNOP00000073634.1, ENSRNOT00000077790.2
    Conserved Domains (1) summary
    pfam00375
    Location:50385
    SDF; Sodium:dicarboxylate symporter family
  4. NM_019225.2NP_062098.1  excitatory amino acid transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_062098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Glast) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF265360, FM094687, FQ097869, S59158
    UniProtKB/Swiss-Prot
    P24942
    UniProtKB/TrEMBL
    G3V846
    Related
    ENSRNOP00000022319.3, ENSRNOT00000022319.7
    Conserved Domains (1) summary
    pfam00375
    Location:50497
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    57755495..57830605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)