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Slc1a2 solute carrier family 1 member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29482, updated on 8-Dec-2022

Summary

Official Symbol
Slc1a2provided by RGD
Official Full Name
solute carrier family 1 member 2provided by RGD
Primary source
RGD:3697
See related
Ensembl:ENSRNOG00000005479 AllianceGenome:RGD:3697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Glt; Eaat2; Glt-1
Summary
Enables high-affinity glutamate transmembrane transporter activity. Involved in L-glutamate transmembrane transport. Located in several cellular components, including astrocyte projection; dendrite; and presynaptic membrane. Is integral component of plasma membrane. Part of membrane protein complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Expression
Restricted expression toward (RPKM 1451.5) See more
Orthologs
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Genomic context

See Slc1a2 in Genome Data Viewer
Location:
3q32
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (89005129..89126498)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (92518679..92665731)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene four-jointed box kinase 1 Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene uncharacterized LOC120101608 Neighboring gene CD44 molecule (Indian blood group) Neighboring gene ribosomal protein S8, pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables acidic amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate:sodium symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables high-affinity L-glutamate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables high-affinity L-glutamate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables high-affinity L-glutamate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables high-affinity L-glutamate transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables organic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in D-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-glutamate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in acidic amino acid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within adult behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cocaine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to extracellular stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cysteine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in dicarboxylic acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in glutathione biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic anion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism aging ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter reuptake ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter transport TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotrimerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotrimerization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within response to amino acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within telencephalon development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visual behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
located_in axolemma ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of membrane protein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of membrane protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
excitatory amino acid transporter 2
Names
glial glutamate transporter GLT1/V3
glial glutamate transporter GLT1/V4
glutamate transporter 1
high affinity glucose transporter
sodium-dependent glutamate/aspartate transporter 2
solute carrier family 1 (glial high affinity glutamate transporter), member 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035233.2NP_001030310.2  excitatory amino acid transporter 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000118
    UniProtKB/TrEMBL
    A0A8I6AL04
    Related
    ENSRNOP00000094162.1, ENSRNOT00000109994.1
    Conserved Domains (1) summary
    pfam00375
    Location:46495
    SDF; Sodium:dicarboxylate symporter family
  2. NM_001302089.2NP_001289018.1  excitatory amino acid transporter 2 isoform c

    See identical proteins and their annotated locations for NP_001289018.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000118
    UniProtKB/Swiss-Prot
    P31596
    Related
    ENSRNOP00000007604.7, ENSRNOT00000007604.7
    Conserved Domains (1) summary
    pfam00375
    Location:43492
    SDF; Sodium:dicarboxylate symporter family
  3. NM_017215.3NP_058911.2  excitatory amino acid transporter 2 isoform a

    See identical proteins and their annotated locations for NP_058911.2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000118
    UniProtKB/Swiss-Prot
    P31596
    UniProtKB/TrEMBL
    Q8K5B5
    Related
    ENSRNOP00000097282.1, ENSRNOT00000099140.1
    Conserved Domains (1) summary
    pfam00375
    Location:46495
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    89005129..89126498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)