Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adamts12provided by RGD
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 12provided by RGD
Primary source: RGD:1307323
See related: Ensembl:ENSRNOG00000018865 AllianceGenome:RGD:1307323
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of cellular response to growth factor stimulus; protein catabolic process; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Heart (RPKM 144.1), Lung (RPKM 89.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (61759975..62054716)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (60032873..60327629)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (61039072..61340687)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis.
Title: Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis.
ADAMTS-7 and ADAMTS-12 expression were dramatically increased during disc degeneration.
Title: Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc.

Submit: New GeneRIF Correction

General gene information

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Markers

D2Rat271 (e-PCR), detects polymorphism
- UniSTS:227411

AU027885 (e-PCR)
- UniSTS:112869

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular response to hepatocyte growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular response to hepatocyte growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in ossification involved in bone maturation	IEA Inferred from Electronic Annotation more info
involved_in ossification involved in bone maturation	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteoglycan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan metabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteoglycan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial tube morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 12

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106420.4 → NP_001099890.2 A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

D3ZTJ3

Related

ENSRNOP00000025693.6, ENSRNOT00000025693.9

Conserved Domains (7) summary

smart00209
Location:549 → 600

TSP1; Thrombospondin type 1 repeats

cd04273
Location:250 → 457

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:250 → 460

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:80 → 196

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:706 → 816

ADAM_spacer1; ADAM-TS Spacer 1

pfam17061
Location:1021 → 1176

PARM; PARM

cl15456
Location:519 → 680

ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

61759975..62054716

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101948.2 → XP_038957876.1 A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1

Conserved Domains (7) summary

smart00209
Location:549 → 600

TSP1; Thrombospondin type 1 repeats

cd04273
Location:250 → 457

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:706 → 816

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:53 → 197

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:472 → 536

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:952 → 1000

TSP1_ADAMTS; Thrombospondin type 1 domain

cl15456
Location:519 → 680

ADAM_CR; ADAM cysteine-rich