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Rad1 RAD1 checkpoint DNA exonuclease [ Rattus norvegicus (Norway rat) ]

Gene ID: 294800, updated on 18-Apr-2019

Summary

Official Symbol
Rad1provided by RGD
Official Full Name
RAD1 checkpoint DNA exonucleaseprovided by RGD
Primary source
RGD:1306496
See related
Ensembl:ENSRNOG00000018063
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Thymus (RPKM 77.5), Spleen (RPKM 64.8) and 9 other tissues See more
Orthologs

Genomic context

See Rad1 in Genome Data Viewer
Location:
2q16
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (60461513..60469646)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (84204582..84212699, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene biogenesis of ribosomes BRX1 Neighboring gene 39S ribosomal protein L40, mitochondrial-like Neighboring gene uncharacterized LOC108349965

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
3'-5' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
PubMed 
meiotic recombination checkpoint IEA
Inferred from Electronic Annotation
more info
 
meiotic recombination checkpoint ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
cell cycle checkpoint protein RAD1
Names
RAD1 homolog
NP_001099889.1
XP_006232120.1
XP_006232121.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106419.1NP_001099889.1  cell cycle checkpoint protein RAD1

    See identical proteins and their annotated locations for NP_001099889.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474058
    UniProtKB/TrEMBL
    D3ZC52
    Conserved Domains (2) summary
    cd00577
    Location:19276
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam02144
    Location:17257
    Rad1; Repair protein Rad1/Rec1/Rad17

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    60461513..60469646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232058.3XP_006232120.1  cell cycle checkpoint protein RAD1 isoform X1

    See identical proteins and their annotated locations for XP_006232120.1

    UniProtKB/TrEMBL
    D3ZC52
    Related
    ENSRNOP00000024557.4, ENSRNOT00000024557.6
    Conserved Domains (2) summary
    cd00577
    Location:19276
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam02144
    Location:17257
    Rad1; Repair protein Rad1/Rec1/Rad17
  2. XM_006232059.3XP_006232121.1  cell cycle checkpoint protein RAD1 isoform X1

    See identical proteins and their annotated locations for XP_006232121.1

    UniProtKB/TrEMBL
    D3ZC52
    Conserved Domains (2) summary
    cd00577
    Location:19276
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam02144
    Location:17257
    Rad1; Repair protein Rad1/Rec1/Rad17

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    59204129..59212168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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