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Rad1 RAD1 checkpoint DNA exonuclease [ Rattus norvegicus (Norway rat) ]

Gene ID: 294800, updated on 5-Mar-2024

Summary

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Official Symbol
Rad1provided by RGD
Official Full Name
RAD1 checkpoint DNA exonucleaseprovided by RGD
Primary source
RGD:1306496
See related
Ensembl:ENSRNOG00000018063 AllianceGenome:RGD:1306496
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 3'-5' exonuclease activity. Predicted to be involved in several processes, including cellular response to ionizing radiation; negative regulation of cell cycle phase transition; and substantia nigra development. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 77.5), Spleen (RPKM 64.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q16
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (61188755..61196868)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (59461597..59469707)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (60461513..60469646)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene biogenesis of ribosomes BRX1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene mitochondrial ribosomal protein L40, pseudogene 1 Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rad1 attenuates DNA double-strand breaks and cell cycle arrest in type II alveolar epithelial cells of rats with bronchopulmonary dysplasia. Tong X, et al. Mol Med, 2023 May 24. PMID 37226090, Free PMC Article
  2. Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. Freire R, et al. Genes Dev, 1998 Aug 15. PMID 9716408, Free PMC Article
  3. A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. Parker AE, et al. J Biol Chem, 1998 Jul 17. PMID 9660799
  4. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Cotta-Ramusino C, et al. Science, 2011 Jun 10. PMID 21659603, Free PMC Article
  5. Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Chen S, et al. Neurochem Res, 2012 Dec. PMID 22926577

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rad1 attenuates DNA double-strand breaks and cell cycle arrest in type II alveolar epithelial cells of rats with bronchopulmonary dysplasia.
    Title: Rad1 attenuates DNA double-strand breaks and cell cycle arrest in type II alveolar epithelial cells of rats with bronchopulmonary dysplasia.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic recombination checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of checkpoint clamp complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell cycle checkpoint protein RAD1
Names
RAD1 homolog
NP_001099889.1
XP_006232120.1
XP_006232121.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106419.1 → NP_001099889.1  cell cycle checkpoint protein RAD1

    See identical proteins and their annotated locations for NP_001099889.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474058
    UniProtKB/TrEMBL
    A6KJS9, D3ZC52
    Related
    ENSRNOP00000024557.4, ENSRNOT00000024557.7
    Conserved Domains (1) summary
    pfam02144
    Location:17 → 257
    Rad1; Repair protein Rad1/Rec1/Rad17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    61188755..61196868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232058.5 → XP_006232120.1  cell cycle checkpoint protein RAD1 isoform X1

    See identical proteins and their annotated locations for XP_006232120.1

    UniProtKB/TrEMBL
    A6KJS9, D3ZC52
    Conserved Domains (1) summary
    pfam02144
    Location:17 → 257
    Rad1; Repair protein Rad1/Rec1/Rad17

  2. XM_006232059.5 → XP_006232121.1  cell cycle checkpoint protein RAD1 isoform X1

    See identical proteins and their annotated locations for XP_006232121.1

    UniProtKB/TrEMBL
    A6KJS9, D3ZC52
    Conserved Domains (1) summary
    pfam02144
    Location:17 → 257
    Rad1; Repair protein Rad1/Rec1/Rad17

RNA

  1. XR_010063590.1 RNA Sequence

  2. XR_005500255.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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