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Trpv2 transient receptor potential cation channel, subfamily V, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29465, updated on 11-Apr-2024

Summary

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Official Symbol
Trpv2provided by RGD
Official Full Name
transient receptor potential cation channel, subfamily V, member 2provided by RGD
Primary source
RGD:3965
See related
Ensembl:ENSRNOG00000003104 AllianceGenome:RGD:3965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Vrl1
Summary
Enables identical protein binding activity. Involved in negative regulation of cell population proliferation and response to heat. Located in several cellular components, including endomembrane system; lamellipodium; and plasma membrane. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 104.8), Lung (RPKM 91.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (47772223..47797956)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (47265524..47294263)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48903540..48925036)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene thymosin beta-4-like Neighboring gene ubiquitin B Neighboring gene small nucleolar RNA SNORA29 Neighboring gene small nucleolar RNA, C/D box 49B Neighboring gene small nucleolar RNA, C/D box 49A Neighboring gene small nucleolar RNA, C/D box 65 Neighboring gene leucine rich repeat containing 75A Neighboring gene uncharacterized LOC120095115 Neighboring gene membrane magnesium transporter 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats. O'Hare M, et al. JCI Insight, 2022 Sep 22. PMID 36134661, Free PMC Article
  2. Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel. Mo X, et al. Elife, 2022 Jun 10. PMID 35686730, Free PMC Article
  3. Identification of a helix-turn-helix motif for high temperature dependence of vanilloid receptor TRPV2. Liu B, et al. J Physiol, 2021 Nov. PMID 34605028
  4. Molecular mechanism of TRPV2 channel modulation by cannabidiol. Pumroy RA, et al. Elife, 2019 Sep 30. PMID 31566564, Free PMC Article
  5. Involvement of transient receptor potential vanilloid 2 in intra-oral incisional pain. Urata K, et al. Oral Dis, 2018 Sep. PMID 29505690

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats.
    Title: The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats.
  2. Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.
    Title: Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.
  3. Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats.
    Title: Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats.
  4. Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel.
    Title: Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel.
  5. Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment.
    Title: Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment.
  6. Identification of a helix-turn-helix motif for high temperature dependence of vanilloid receptor TRPV2.
    Title: Identification of a helix-turn-helix motif for high temperature dependence of vanilloid receptor TRPV2.
  7. Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2.
    Title: Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2.
  8. miR-202-5p protects rat against myocardial ischemia reperfusion injury by downregulating the expression of Trpv2 to attenuate the Ca (2+) overload in cardiomyocytes.
    Title: miR-202-5p protects rat against myocardial ischemia reperfusion injury by downregulating the expression of Trpv2 to attenuate the Ca (2+) overload in cardiomyocytes.
  9. the selectivity filters in TRPV1-3 channels do not function as activation gates
    Title: The ion selectivity filter is not an activation gate in TRPV1-3 channels.
  10. A methionine-dependent redox sensitivity of TRPV2 which may be an important endogenous mechanism for regulation of TRPV2 activity and account for its pivotal role for phagocytosis in macrophages.
    Title: Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2.
Submit: New GeneRIF Correction See all GeneRIFs (47)

General gene information

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Markers

Homology

Clone Names

  • MGC105451

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion import IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to temperature stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to temperature stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axonal growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in cell body IEA
Inferred from Electronic Annotation
more info
  
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone membrane IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel subfamily V member 2
Names
OTRPC2
VRL-1
osm-9-like TRP channel 2
stretch-activated channel 2B
vanilloid receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270797.1 → NP_001257726.1  transient receptor potential cation channel subfamily V member 2

    See identical proteins and their annotated locations for NP_001257726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC089215, JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q5FWT3, Q9JMI8, Q9QYH8, Q9WUD2
    UniProtKB/TrEMBL
    A0A0G2JSH6
    Conserved Domains (2) summary
    sd00045
    Location:164 → 194
    ANK; ANK repeat [structural motif]
    cd22197
    Location:71 → 710
    TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

  2. NM_001270798.1 → NP_001257727.1  transient receptor potential cation channel subfamily V member 2

    See identical proteins and their annotated locations for NP_001257727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC089215, JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q5FWT3, Q9JMI8, Q9QYH8, Q9WUD2
    UniProtKB/TrEMBL
    A0A0G2JSH6
    Conserved Domains (2) summary
    sd00045
    Location:164 → 194
    ANK; ANK repeat [structural motif]
    cd22197
    Location:71 → 710
    TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

  3. NM_017207.3 → NP_058903.2  transient receptor potential cation channel subfamily V member 2

    See identical proteins and their annotated locations for NP_058903.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    BC089215, JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q5FWT3, Q9JMI8, Q9QYH8, Q9WUD2
    UniProtKB/TrEMBL
    A0A0G2JSH6
    Related
    ENSRNOP00000004248.4, ENSRNOT00000004248.7
    Conserved Domains (2) summary
    sd00045
    Location:164 → 194
    ANK; ANK repeat [structural motif]
    cd22197
    Location:71 → 710
    TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    47772223..47797956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268817.1 → XP_063124887.1  transient receptor potential cation channel subfamily V member 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSH6

  2. XM_063268816.1 → XP_063124886.1  transient receptor potential cation channel subfamily V member 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSH6

  3. XM_063268815.1 → XP_063124885.1  transient receptor potential cation channel subfamily V member 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSH6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUD2.2 GenPept UniProtKB/Swiss-Prot:Q9WUD2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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