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Slc6a6 solute carrier family 6 member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29464, updated on 12-Jan-2022

Summary

Official Symbol
Slc6a6provided by RGD
Official Full Name
solute carrier family 6 member 6provided by RGD
Primary source
RGD:61912
See related
Ensembl:ENSRNOG00000009019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables gamma-aminobutyric acid transmembrane transporter activity; taurine binding activity; and taurine:sodium symporter activity. Involved in gamma-aminobutyric acid import; import across plasma membrane; and taurine transport. Located in dendrite; neuronal cell body; and plasma membrane. Part of plasma membrane protein complex. Orthologous to human SLC6A6 (solute carrier family 6 member 6). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Adrenal (RPKM 304.5), Kidney (RPKM 299.5) and 9 other tissues See more
Orthologs
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Genomic context

See Slc6a6 in Genome Data Viewer
Location:
4q34
Exon count:
18
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (124195186..124268880)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (123638619..123713469, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene XPC complex subunit, DNA damage recognition and repair factor Neighboring gene LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene uncharacterized LOC102548902 Neighboring gene glutamate receptor interacting protein 2 Neighboring gene 40S ribosomal protein S11-like Neighboring gene coiled-coil domain containing 174

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in alanine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in alanine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in amino acid import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within beta-alanine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in gamma-aminobutyric acid import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gamma-aminobutyric acid import IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in import across plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of nitrogen compound transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of necrotic cell death IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in taurine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in taurine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in taurine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in taurine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within taurine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in taurine transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of plasma membrane protein complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
sodium- and chloride-dependent taurine transporter
Names
Solute carrier 6 ,member 6 (taurine transporter)
solute carrier family 6 (neurotransmitter transporter), member 6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
taurine/beta-alanine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017206.2NP_058902.1  sodium- and chloride-dependent taurine transporter

    See identical proteins and their annotated locations for NP_058902.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000148
    UniProtKB/Swiss-Prot
    P31643
    Related
    ENSRNOP00000012875.4, ENSRNOT00000012875.7
    Conserved Domains (1) summary
    cl00456
    Location:41582
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    124195186..124268880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107210.1XP_038963138.1  sodium- and chloride-dependent taurine transporter isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:51342
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_008763123.3XP_008761345.1  sodium- and chloride-dependent taurine transporter isoform X1

    UniProtKB/TrEMBL
    A0A0G2K227
    Related
    ENSRNOP00000094249.1, ENSRNOT00000117501.1
    Conserved Domains (1) summary
    cl00456
    Location:51592
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. XM_006236903.4XP_006236965.1  sodium- and chloride-dependent taurine transporter isoform X2

    See identical proteins and their annotated locations for XP_006236965.1

    UniProtKB/Swiss-Prot
    P31643
    Conserved Domains (1) summary
    cl00456
    Location:41582
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. XM_039107207.1XP_038963135.1  sodium- and chloride-dependent taurine transporter isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:51592
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. XM_039107209.1XP_038963137.1  sodium- and chloride-dependent taurine transporter isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:41582
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  6. XM_039107206.1XP_038963134.1  sodium- and chloride-dependent taurine transporter isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:51592
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  7. XM_039107208.1XP_038963136.1  sodium- and chloride-dependent taurine transporter isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:41582
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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