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Neurod1 neuronal differentiation 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29458, updated on 22-May-2022

Summary

Official Symbol
Neurod1provided by RGD
Official Full Name
neuronal differentiation 1provided by RGD
Primary source
RGD:3165
See related
Ensembl:ENSRNOG00000005609 AllianceGenome:RGD:3165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables double-stranded DNA binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human NEUROD1 (neuronal differentiation 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 254.9) See more
Orthologs
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Genomic context

See Neurod1 in Genome Data Viewer
Location:
3q24
Exon count:
2
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (64360222..64363526, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (66414314..66417617, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 4 Neighboring gene U6 spliceosomal RNA Neighboring gene ceramide kinase-like Neighboring gene uncharacterized LOC102553021 Neighboring gene uncharacterized LOC102553121 Neighboring gene uncharacterized LOC103691830

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in amacrine cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in amacrine cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within camera-type eye development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebellum development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dentate gyrus development ISO
Inferred from Sequence Orthology
more info
 
involved_in dentate gyrus development ISO
Inferred from Sequence Orthology
more info
 
involved_in dentate gyrus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in embryonic organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
involved_in endocrine pancreas development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in enteroendocrine cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in enteroendocrine cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hindbrain development ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear development ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within pancreatic A cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pancreatic PP cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intestinal epithelial structure maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intestinal epithelial structure maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neurogenic differentiation factor 1
Names
BHF-1
basic helix-loop-helix factor 1
neurogenic differentiation 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019218.3NP_062091.1  neurogenic differentiation factor 1

    See identical proteins and their annotated locations for NP_062091.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000115
    UniProtKB/Swiss-Prot
    Q64289
    Related
    ENSRNOP00000007662.5, ENSRNOT00000007662.8
    Conserved Domains (2) summary
    cd19719
    Location:75160
    bHLH_TS_NeuroD1; basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) and similar proteins
    pfam12533
    Location:160284
    Neuro_bHLH; Neuronal helix-loop-helix transcription factor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    64360222..64363526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)