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Pou5f1 POU class 5 homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294562, updated on 12-Aug-2018

Summary

Official Symbol
Pou5f1provided by RGD
Official Full Name
POU class 5 homeobox 1provided by RGD
Primary source
RGD:1359491
See related
Ensembl:ENSRNOG00000046487 Vega:OTTRNOG00000001656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Liver (RPKM 6.5), Thymus (RPKM 3.2) and 8 other tissues See more
Orthologs

Genomic context

See Pou5f1 in Genome Data Viewer
Location:
20p12
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3747231..3751994, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (5833973..5838736, complement)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene psoriasis susceptibility 1 candidate 2 Neighboring gene coiled-coil alpha-helical rod protein 1 Neighboring gene transcription factor 19 Neighboring gene class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like Neighboring gene ring finger protein 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
HMG box domain binding IDA
Inferred from Direct Assay
more info
PubMed 
POU domain binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
cytokine binding ISO
Inferred from Sequence Orthology
more info
 
cytokine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enhancer sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
miRNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
BMP signaling pathway involved in heart induction ISO
Inferred from Sequence Orthology
more info
 
blastocyst development ISO
Inferred from Sequence Orthology
more info
 
blastocyst growth IEA
Inferred from Electronic Annotation
more info
 
blastocyst growth ISO
Inferred from Sequence Orthology
more info
 
cardiac cell fate determination ISO
Inferred from Sequence Orthology
more info
 
cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
cell fate commitment involved in formation of primary germ layer ISO
Inferred from Sequence Orthology
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
ectodermal cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
ectodermal cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
endodermal cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
endodermal cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
endodermal cell fate specification ISO
Inferred from Sequence Orthology
more info
 
germ-line stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
germ-line stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
mRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
mesodermal cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
mesodermal cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of asymmetric cell division IEA
Inferred from Electronic Annotation
more info
 
regulation of asymmetric cell division ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of heart induction by regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of methylation-dependent chromatin silencing ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
trophectodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
trophectodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
nuclear transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
transcriptional repressor complex IEA
Inferred from Electronic Annotation
more info
 
transcriptional repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
POU domain, class 5, transcription factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009178.2NP_001009178.1  POU domain, class 5, transcription factor 1

    See identical proteins and their annotated locations for NP_001009178.1

    Status: VALIDATED

    Source sequence(s)
    BC158566
    UniProtKB/TrEMBL
    Q6MG27
    Related
    ENSRNOP00000065216.1, OTTRNOP00000001507, ENSRNOT00000072288.2, OTTRNOT00000002607
    Conserved Domains (2) summary
    smart00352
    Location:131205
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:226279
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    3747231..3751994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    650325..655095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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