Serinc1 serine incorporator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serinc1provided by RGD
Official Full Name: serine incorporator 1provided by RGD
Primary source: RGD:727843
See related: Ensembl:ENSRNOG00000029360 AllianceGenome:RGD:727843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tde2; Tde1l; LRRGT00191
Summary: Enables acetyltransferase activator activity; enzyme binding activity; and protein-macromolecule adaptor activity. Involved in membrane biogenesis; phosphatidylserine metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum membrane and plasma membrane. Orthologous to human SERINC1 (serine incorporator 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 2684.8), Heart (RPKM 1219.7) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 20q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (37396497..37415433, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (36850062..36868999, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (38966016..38985056, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serinc proteins incorporate serine into membrane lipid synthesis
Title: Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis.

Submit: New GeneRIF Correction

General gene information

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Markers

AU048742 (e-PCR)
- UniSTS:145192

px-34e1 (e-PCR)
- UniSTS:257617

RH133897 (e-PCR)
- UniSTS:217180

px-21d9 (e-PCR)
- UniSTS:257397

px-38b5 (e-PCR)
- UniSTS:257691

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetyltransferase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in membrane biogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylserine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sphingolipid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine incorporator 1

Names: tumor differentially expressed 1, like; tumor differentially expressed protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.