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Rasgrp1 RAS guanyl releasing protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29434, updated on 18-Apr-2019

Summary

Official Symbol
Rasgrp1provided by RGD
Official Full Name
RAS guanyl releasing protein 1provided by RGD
Primary source
RGD:3539
See related
Ensembl:ENSRNOG00000005404
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rasgrp
Summary
putative guanine nucleotide exchange factor with Ca2+ and diacylglycerol binding domains; may activate Rap protein mediated inhibition of Ras signaling pathways [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 342.5), Thymus (RPKM 328.1) and 5 other tissues See more
Orthologs

Genomic context

See Rasgrp1 in Genome Data Viewer
Location:
3q35
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (108984029..109044420, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (115539782..115600270, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene microRNA 674 Neighboring gene family with sequence similarity 98, member B Neighboring gene uncharacterized LOC108350442 Neighboring gene uncharacterized LOC103691867

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Rap guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
PubMed 
Ras guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
diacylglycerol binding IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol binding ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatidylcholine binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatidylserine binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cytokine production IEA
Inferred from Electronic Annotation
more info
 
cytokine production ISO
Inferred from Sequence Orthology
more info
PubMed 
inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
mast cell degranulation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of granulocyte macrophage colony-stimulating factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of granulocyte macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of interferon-gamma secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
PubMed 
protein complex oligomerization IEA
Inferred from Electronic Annotation
more info
 
protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
PubMed 
secretory granule localization IEA
Inferred from Electronic Annotation
more info
 
secretory granule localization ISO
Inferred from Sequence Orthology
more info
PubMed 
vesicle transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
vesicle transport along microtubule ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
mast cell granule IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RAS guanyl-releasing protein 1
Names
CalDAG-GEF1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
calDAG-GEFII
calcium and DAG-regulated guanine nucleotide exchange factor II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019211.2NP_062084.2  RAS guanyl-releasing protein 1

    See identical proteins and their annotated locations for NP_062084.2

    Status: PROVISIONAL

    Source sequence(s)
    AF081196
    UniProtKB/Swiss-Prot
    Q9R1K8
    Related
    ENSRNOP00000007687.4, ENSRNOT00000007687.4
    Conserved Domains (5) summary
    smart00147
    Location:201437
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:54176
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:474521
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:542591
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:478526
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    108984029..109044420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    103097991..103157871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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