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Pak3 p21 (RAC1) activated kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29433, updated on 26-Nov-2020

Summary

Official Symbol
Pak3provided by RGD
Official Full Name
p21 (RAC1) activated kinase 3provided by RGD
Primary source
RGD:3251
See related
Ensembl:ENSRNOG00000004676
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
beta-PAK
Summary
displays GTP-p21 mediated protein kinase activity [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 136.9), Testes (RPKM 64.9) and 2 other tissues See more
Orthologs

Genomic context

See Pak3 in Genome Data Viewer
Location:
Xq33
Exon count:
22
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (114784452..115042683)
106 current Rn_Celera (GCF_000002265.2) X AC_000089.1 (106660352..106767478)
104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (113227320..113495881)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene hypothetical LOC100364395 Neighboring gene chordin-like 1 Neighboring gene calpain 6 Neighboring gene doublecortin

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
MAP kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
dendrite development ISO
Inferred from Sequence Orthology
more info
 
dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
positive regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 3
Names
PAK-3
p21 (CDKN1A)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21-activated kinase 3
p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related)
p65-PAK
NP_062083.1
XP_006257395.1
XP_006257401.1
XP_008771626.1
XP_017457426.1
XP_017457427.1
XP_017457428.1
XP_017457429.1
XP_017457430.1
XP_017457431.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019210.2NP_062083.1  serine/threonine-protein kinase PAK 3

    See identical proteins and their annotated locations for NP_062083.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000448
    UniProtKB/Swiss-Prot
    Q62829
    Related
    ENSRNOP00000006459.4, ENSRNOT00000006459.5
    Conserved Domains (3) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:268519
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    114784452..115042683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601940.1XP_017457429.1  serine/threonine-protein kinase PAK 3 isoform X1

    Conserved Domains (3) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:304555
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69160
    PBD; P21-Rho-binding domain
  2. XM_017601937.1XP_017457426.1  serine/threonine-protein kinase PAK 3 isoform X1

    Conserved Domains (3) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:304555
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69160
    PBD; P21-Rho-binding domain
  3. XM_008773404.2XP_008771626.1  serine/threonine-protein kinase PAK 3 isoform X1

    Conserved Domains (3) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:304555
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69160
    PBD; P21-Rho-binding domain
  4. XM_017601939.1XP_017457428.1  serine/threonine-protein kinase PAK 3 isoform X1

    Conserved Domains (3) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:304555
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69160
    PBD; P21-Rho-binding domain
  5. XM_017601938.1XP_017457427.1  serine/threonine-protein kinase PAK 3 isoform X1

    Conserved Domains (3) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:304555
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69160
    PBD; P21-Rho-binding domain
  6. XM_017601942.1XP_017457431.1  serine/threonine-protein kinase PAK 3 isoform X1

    Conserved Domains (3) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:304555
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69160
    PBD; P21-Rho-binding domain
  7. XM_006257333.3XP_006257395.1  serine/threonine-protein kinase PAK 3 isoform X2

    See identical proteins and their annotated locations for XP_006257395.1

    Conserved Domains (3) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:283534
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  8. XM_006257339.3XP_006257401.1  serine/threonine-protein kinase PAK 3 isoform X3

    See identical proteins and their annotated locations for XP_006257401.1

    UniProtKB/Swiss-Prot
    Q62829
    Conserved Domains (3) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:268519
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  9. XM_017601941.1XP_017457430.1  serine/threonine-protein kinase PAK 3 isoform X1

    Conserved Domains (3) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:304555
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69160
    PBD; P21-Rho-binding domain

Alternate Rn_Celera

Genomic

  1. AC_000089.1 Alternate Rn_Celera

    Range
    106660352..106767478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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