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Pak1 p21 (RAC1) activated kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29431, updated on 22-May-2022

Summary

Official Symbol
Pak1provided by RGD
Official Full Name
p21 (RAC1) activated kinase 1provided by RGD
Primary source
RGD:3250
See related
Ensembl:ENSRNOG00000029784 AllianceGenome:RGD:3250
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; nervous system development; and positive regulation of cell migration. Located in several cellular components, including Z disc; intercalated disc; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 564.9), Adrenal (RPKM 131.3) and 7 other tissues See more
Orthologs
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Genomic context

See Pak1 in Genome Data Viewer
Location:
1q32
Exon count:
18
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (152111172..152226390)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (162768156..162883356)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550562 Neighboring gene aquaporin 11 Neighboring gene high-mobility group box 1, pseudogene 23 Neighboring gene transfer RNA glycine (anticodon ACC) Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene pyruvate kinase M1/2, pseudogene 7 Neighboring gene myosin VIIA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables gamma-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
NOT involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within amygdala development ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
involved_in branching morphogenesis of an epithelial tube ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within dendrite development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gamma-aminobutyric acid secretion, neurotransmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glutamate secretion, neurotransmission ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell proliferation involved in contact inhibition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell proliferation involved in contact inhibition ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within observational learning ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 1
Names
PAK-1
alpha-PAK
p21 (CDKN1A)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21-activated kinase 1
p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
p68-PAK
protein kinase MUK2
NP_058894.1
XP_006229814.1
XP_006229815.1
XP_006229816.1
XP_038965318.1
XP_038965324.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017198.2NP_058894.1  serine/threonine-protein kinase PAK 1

    See identical proteins and their annotated locations for NP_058894.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000042
    UniProtKB/Swiss-Prot
    P35465
    Related
    ENSRNOP00000085225.1, ENSRNOT00000104124.1
    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    152111172..152226390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109396.1XP_038965324.1  serine/threonine-protein kinase PAK 1 isoform X1

    Related
    ENSRNOP00000073036.1, ENSRNOT00000091952.2
    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  2. XM_006229754.4XP_006229816.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_006229816.1

    UniProtKB/Swiss-Prot
    P35465
    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  3. XM_039109390.1XP_038965318.1  serine/threonine-protein kinase PAK 1 isoform X1

    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  4. XM_006229753.3XP_006229815.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_006229815.1

    UniProtKB/Swiss-Prot
    P35465
    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  5. XM_006229752.3XP_006229814.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_006229814.1

    UniProtKB/Swiss-Prot
    P35465
    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain