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Pak1 p21 (RAC1) activated kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29431, updated on 19-Apr-2019

Summary

Official Symbol
Pak1provided by RGD
Official Full Name
p21 (RAC1) activated kinase 1provided by RGD
Primary source
RGD:3250
See related
Ensembl:ENSRNOG00000029784
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
serine/threonine protein kinase; binds and forms complex specifically with activated (GTP-bound) p21, leading to inhibiting p21 GTPase activity [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 564.9), Adrenal (RPKM 131.3) and 7 other tissues See more
Orthologs

Genomic context

See Pak1 in Genome Data Viewer
Location:
1q32
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (162768156..162883356)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (168974734..169090326)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550562 Neighboring gene aquaporin 11 Neighboring gene similar to High mobility group protein 1 (HMG-1) (High mobility group protein B1) (Amphoterin) (Heparin-binding protein p30) Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene similar to pyruvate kinase 3 Neighboring gene myosin VIIA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity TAS
Traceable Author Statement
more info
PubMed 
Rac GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to Rac GTPase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
collagen binding ISO
Inferred from Sequence Orthology
more info
PubMed 
collagen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
NOT MAPK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
PubMed 
actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amygdala development ISO
Inferred from Sequence Orthology
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
PubMed 
branching morphogenesis of an epithelial tube ISS
Inferred from Sequence or Structural Similarity
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
chromatin remodeling ISO
Inferred from Sequence Orthology
more info
PubMed 
chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite development ISO
Inferred from Sequence Orthology
more info
PubMed 
dendritic spine development ISO
Inferred from Sequence Orthology
more info
PubMed 
establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
gamma-aminobutyric acid secretion, neurotransmission ISO
Inferred from Sequence Orthology
more info
PubMed 
glutamate secretion, neurotransmission ISO
Inferred from Sequence Orthology
more info
PubMed 
hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation involved in contact inhibition ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell proliferation involved in contact inhibition ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
observational learning ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of intracellular estrogen receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of microtubule polymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
receptor clustering ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
PubMed 
transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
PubMed 
wound healing ISO
Inferred from Sequence Orthology
more info
PubMed 
wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
actin filament IEA
Inferred from Electronic Annotation
more info
 
actin filament ISO
Inferred from Sequence Orthology
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
PubMed 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
growth cone ISO
Inferred from Sequence Orthology
more info
PubMed 
intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
invadopodium ISO
Inferred from Sequence Orthology
more info
PubMed 
invadopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
ruffle ISO
Inferred from Sequence Orthology
more info
PubMed 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 1
Names
PAK-1
alpha-PAK
p21 (CDKN1A)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21-activated kinase 1
p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
p68-PAK
protein kinase MUK2
NP_058894.1
XP_006229814.1
XP_006229815.1
XP_006229816.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017198.1NP_058894.1  serine/threonine-protein kinase PAK 1

    See identical proteins and their annotated locations for NP_058894.1

    Status: PROVISIONAL

    Source sequence(s)
    U49953
    UniProtKB/Swiss-Prot
    P35465
    Related
    ENSRNOP00000045832.3, ENSRNOT00000049321.4
    Conserved Domains (3) summary
    smart00220
    Location:269520
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74129
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    162768156..162883356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229754.3XP_006229816.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_006229816.1

    UniProtKB/Swiss-Prot
    P35465
    Conserved Domains (3) summary
    smart00220
    Location:269520
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74129
    PBD; P21-Rho-binding domain
  2. XM_006229752.2XP_006229814.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_006229814.1

    UniProtKB/Swiss-Prot
    P35465
    Related
    ENSRNOP00000073036.1, ENSRNOT00000091952.1
    Conserved Domains (3) summary
    smart00220
    Location:269520
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74129
    PBD; P21-Rho-binding domain
  3. XM_006229753.2XP_006229815.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_006229815.1

    UniProtKB/Swiss-Prot
    P35465
    Conserved Domains (3) summary
    smart00220
    Location:269520
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74129
    PBD; P21-Rho-binding domain

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    150203043..150317598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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