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Celf2 CUGBP, Elav-like family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29428, updated on 18-Apr-2019

Summary

Official Symbol
Celf2provided by RGD
Official Full Name
CUGBP, Elav-like family member 2provided by RGD
Primary source
RGD:68347
See related
Ensembl:ENSRNOG00000023661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Etr3; Napor; Cugbp2; Brunol3
Summary
RNA binding protein that binds to two sets of AU-rich sequences in COX2; involved in mRNA stabilization and translational silencing [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 283.6), Spleen (RPKM 168.2) and 9 other tissues See more
Orthologs

Genomic context

See Celf2 in Genome Data Viewer
Location:
17q12.3
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (75259269..75660154)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (76413318..77317256)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694127 Neighboring gene uncharacterized LOC102547255 Neighboring gene uncharacterized LOC108353152 Neighboring gene uncharacterized LOC108348587 Neighboring gene USP6 N-terminal like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' pol...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
mRNA splice site selection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splice site selection IEA
Inferred from Electronic Annotation
more info
 
mRNA splice site selection ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CUGBP Elav-like family member 2
Names
CUG triplet repeat, RNA binding protein 2
CUG-BP- and ETR-3-like factor 2
Cugbp- and Etr3-like factor 2
RNA-binding protein BRUNOL-3
RNA-binding protein Brunol3
bruno-like protein 3
elav-type RNA-binding protein 3
neuroblastoma apoptosis-related RNA-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083586.2NP_001077055.2  CUGBP Elav-like family member 2 isoform 2

    See identical proteins and their annotated locations for NP_001077055.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AABR07028568, AABR07028570
    Conserved Domains (3) summary
    cd12631
    Location:57140
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:149229
    RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12638
    Location:434525
    RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
  2. NM_017197.3NP_058893.2  CUGBP Elav-like family member 2 isoform 1

    See identical proteins and their annotated locations for NP_058893.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AABR07028568, AABR07028570
    UniProtKB/Swiss-Prot
    Q792H5
    Conserved Domains (3) summary
    cd12631
    Location:57140
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:149229
    RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12638
    Location:440531
    RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    75259269..75660154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600505.1XP_017455994.1  CUGBP Elav-like family member 2 isoform X8

  2. XM_017600506.1XP_017455995.1  CUGBP Elav-like family member 2 isoform X9

    Conserved Domains (5) summary
    cd12631
    Location:46129
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:138218
    RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12638
    Location:429520
    RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    TIGR01661
    Location:49516
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl00310
    Location:316371
    AIRC; AIR carboxylase
  3. XM_017600507.1XP_017455996.1  CUGBP Elav-like family member 2 isoform X10

    UniProtKB/TrEMBL
    Z4YNP1
    Related
    ENSRNOP00000023436.4, ENSRNOT00000023436.4
    Conserved Domains (3) summary
    cd12631
    Location:46129
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:138218
    RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12638
    Location:423514
    RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
  4. XM_017600501.1XP_017455990.1  CUGBP Elav-like family member 2 isoform X4

  5. XM_017600502.1XP_017455991.1  CUGBP Elav-like family member 2 isoform X5

  6. XM_008771863.2XP_008770085.1  CUGBP Elav-like family member 2 isoform X2

    Conserved Domains (4) summary
    cd12631
    Location:1598
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:107187
    RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12638
    Location:396487
    RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    TIGR01661
    Location:18483
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  7. XM_017600503.1XP_017455992.1  CUGBP Elav-like family member 2 isoform X6

  8. XM_008771862.2XP_008770084.1  CUGBP Elav-like family member 2 isoform X1

    See identical proteins and their annotated locations for XP_008770084.1

    UniProtKB/Swiss-Prot
    Q792H5
    Conserved Domains (3) summary
    cd12631
    Location:1598
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:107187
    RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12638
    Location:398489
    RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
  9. XM_008771864.2XP_008770086.1  CUGBP Elav-like family member 2 isoform X3

    See identical proteins and their annotated locations for XP_008770086.1

    UniProtKB/Swiss-Prot
    Q792H5
    Conserved Domains (3) summary
    cd12631
    Location:1598
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:107187
    RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12638
    Location:392483
    RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
  10. XM_017600504.1XP_017455993.1  CUGBP Elav-like family member 2 isoform X7

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    70868671..71183253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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