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Ddah2 dimethylarginine dimethylaminohydrolase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294239, updated on 2-Oct-2018

Summary

Official Symbol
Ddah2provided by RGD
Official Full Name
dimethylarginine dimethylaminohydrolase 2provided by RGD
Primary source
RGD:1302955
See related
Ensembl:ENSRNOG00000000842 Vega:OTTRNOG00000001823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
human and mouse homologs regulate the concentration of methylarginines [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 173.3), Kidney (RPKM 150.6) and 9 other tissues See more
Orthologs

Genomic context

See Ddah2 in Genome Data Viewer
Location:
20p12
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5049260..5052573)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (7122457..7125503)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene mutS homolog 5 Neighboring gene chloride intracellular channel 1 Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene lymphocyte antigen 6 family member G6C

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105993

Gene Ontology Provided by RGD

Function Evidence Code Pubs
amino acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
dimethylargininase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dimethylargininase activity IDA
Inferred from Direct Assay
more info
PubMed 
dimethylargininase activity ISO
Inferred from Sequence Orthology
more info
 
dimethylargininase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
arginine catabolic process IEA
Inferred from Electronic Annotation
more info
 
arginine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arginine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
citrulline metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
citrulline metabolic process ISO
Inferred from Sequence Orthology
more info
 
citrulline metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nitric oxide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
Names
DDAH-2
DDAHII
dimethylargininase-2
NP_001159408.1
NP_997697.1
XP_008770937.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165936.1NP_001159408.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

    See identical proteins and their annotated locations for NP_001159408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC097930, EV770973
    UniProtKB/Swiss-Prot
    Q6MG60
    Related
    ENSRNOP00000068864.1, OTTRNOP00000001731, ENSRNOT00000083353.1, OTTRNOT00000002932
    Conserved Domains (1) summary
    cl19186
    Location:62277
    Amidinotransf; Amidinotransferase
  2. NM_212532.2NP_997697.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

    See identical proteins and their annotated locations for NP_997697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC097930, CO385374
    UniProtKB/Swiss-Prot
    Q6MG60
    Related
    ENSRNOP00000001118.2, OTTRNOP00000001730, ENSRNOT00000001118.5, OTTRNOT00000002931
    Conserved Domains (1) summary
    cl19186
    Location:62277
    Amidinotransf; Amidinotransferase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    5049260..5052573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772715.2XP_008770937.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform X1

    Conserved Domains (1) summary
    cl19186
    Location:62166
    Amidinotransf; Amidinotransferase

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    4261560..4264603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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