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Trim10 tripartite motif-containing 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294210, updated on 3-Jun-2026
Official Symbol
Trim10provided by RGD
Official Full Name
tripartite motif-containing 10provided by RGD
Primary source
RGD:1359438
See related
Ensembl:ENSRNOG00000000782 AllianceGenome:RGD:1359438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rnf9; Rfb30
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in host-mediated suppression of symbiont invasion. Predicted to act upstream of or within erythrocyte differentiation. Predicted to be active in cytoplasm. Orthologous to human TRIM10 (tripartite motif containing 10). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward (RPKM 105.4) See more
Orthologs
all
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Try the new Transcripts and proteins table
See Trim10 in Genome Data Viewer
Location:
20p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (1694771..1703724, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (1689554..1698948, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (2182945..2191640, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein 39 pseudogene 1 Neighboring gene Pbp pseudogene Neighboring gene tripartite motif containing 15 Neighboring gene tripartite motif-containing 15, pseudogene 1 Neighboring gene tripartite motif-containing 26 Neighboring gene small nucleolar RNA SNORA51

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Silencing of TRIM10 alleviates apoptosis in cellular model of Parkinson's disease. Huang Q, et al. Biochem Biophys Res Commun, 2019 Oct 20. PMID 31472958
  2. Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway. Yang H, et al. J Cell Mol Med, 2020 Jun. PMID 32343488, Free PMC Article
  3. HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. Harada H, et al. Mol Cell Biol, 1999 May. PMID 10207104, Free PMC Article
  4. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. Uchil PD, et al. PLoS Pathog, 2008 Feb 8. PMID 18248090, Free PMC Article
  5. The tripartite motif family identifies cell compartments. Reymond A, et al. EMBO J, 2001 May 1. PMID 11331580, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in host-mediated suppression of symbiont invasion IEA
Inferred from Electronic Annotation
more info
  
involved_in host-mediated suppression of symbiont invasion ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
tripartite motif-containing protein 10
Names
tripartite motif protein 10

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009176.2 → NP_001009176.1  tripartite motif-containing protein 10

    See identical proteins and their annotated locations for NP_001009176.1

    Status: VALIDATED

    Source sequence(s)
    BC129078
    UniProtKB/TrEMBL
    A1L1I7, Q6MFY9
    Related
    ENSRNOP00000001016.5, ENSRNOT00000001016.9
    Conserved Domains (4) summary
    cd00021
    Location:97 → 135
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam15227
    Location:16 → 60
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15827
    Location:309 → 480
    SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
    cl23765
    Location:143 → 217
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    1694771..1703724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278992.1 → XP_063135062.1  tripartite motif-containing protein 10 isoform X1

  2. XM_063278993.1 → XP_063135063.1  tripartite motif-containing protein 10 isoform X2

  3. XM_039098472.2 → XP_038954400.1  tripartite motif-containing protein 10 isoform X3

    Conserved Domains (4) summary
    smart00502
    Location:150 → 224
    BBC; B-Box C-terminal domain
    cd15827
    Location:316 → 487
    SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
    cd16593
    Location:13 → 61
    RING-HC_TRIM10_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 10 (TRIM10) and similar proteins
    cl00034
    Location:99 → 135
    Bbox_SF; B-box-type zinc finger superfamily

  4. XM_039098474.2 → XP_038954402.1  tripartite motif-containing protein 10 isoform X6

    Conserved Domains (4) summary
    smart00502
    Location:150 → 224
    BBC; B-Box C-terminal domain
    cd00162
    Location:16 → 60
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:99 → 135
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:13 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  5. XM_039098473.2 → XP_038954401.1  tripartite motif-containing protein 10 isoform X5

    Conserved Domains (4) summary
    smart00502
    Location:150 → 224
    BBC; B-Box C-terminal domain
    cd00162
    Location:16 → 60
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:99 → 135
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:13 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  6. XM_063278994.1 → XP_063135064.1  tripartite motif-containing protein 10 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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