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Urod uroporphyrinogen decarboxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 29421, updated on 10-Jul-2024

Summary

Official Symbol
Urodprovided by RGD
Official Full Name
uroporphyrinogen decarboxylaseprovided by RGD
Primary source
RGD:3946
See related
EnsemblRapid:ENSRNOG00000018211 AllianceGenome:RGD:3946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
porphyrinogen carboxy-lyase
Summary
Enables ferrous iron binding activity and uroporphyrinogen decarboxylase activity. Involved in several processes, including porphyrin-containing compound metabolic process; response to estradiol; and response to fungicide. Located in cytosol. Biomarker of porphyria and porphyria cutanea tarda. Human ortholog(s) of this gene implicated in porphyria cutanea tarda. Orthologous to human UROD (uroporphyrinogen decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 604.9), Heart (RPKM 372.8) and 9 other tissues See more
Orthologs
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Genomic context

See Urod in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135701294..135705380, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130464695..130468783, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135855429..135859515, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger, SWIM-type containing 5 Neighboring gene large ribosomal subunit protein eL18-like Neighboring gene 40S ribosomal protein S12-like Neighboring gene HECT domain E3 ubiquitin protein ligase 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
PubMed 
enables uroporphyrinogen decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables uroporphyrinogen decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables uroporphyrinogen decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables uroporphyrinogen decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables uroporphyrinogen decarboxylase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in heme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme B biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme B biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme O biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme O biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme biosynthetic process IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within heme metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in liver development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in porphyrin-containing compound biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in porphyrin-containing compound catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in porphyrin-containing compound catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in porphyrin-containing compound catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in porphyrin-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to amine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to fungicide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to iron ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mercury ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to methylmercury IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in uroporphyrinogen III metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
uroporphyrinogen decarboxylase
Names
UPD
URO-D
porphyrinogen carboxylase
uroporphyrinogen III decarboxylase
NP_062082.1
XP_038965299.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019209.1NP_062082.1  uroporphyrinogen decarboxylase

    See identical proteins and their annotated locations for NP_062082.1

    Status: VALIDATED

    Source sequence(s)
    BF414694, BI282626, DY314066, EV767503
    UniProtKB/Swiss-Prot
    P32362
    UniProtKB/TrEMBL
    A0A9K3Y7K6, B0BN55, F1LMP0
    Related
    ENSRNOP00000024719.5, ENSRNOT00000024719.8
    Conserved Domains (1) summary
    cd00717
    Location:20359
    URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    135701294..135705380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109371.2XP_038965299.1  uroporphyrinogen decarboxylase isoform X1

    Conserved Domains (1) summary
    cd00717
    Location:1264
    URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...