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Neurog1 neurogenin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29410, updated on 22-Sep-2022

Summary

Official Symbol
Neurog1provided by RGD
Official Full Name
neurogenin 1provided by RGD
Primary source
RGD:3167
See related
Ensembl:ENSRNOG00000022405 AllianceGenome:RGD:3167
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ngn1; Neurod3
Summary
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including animal organ morphogenesis; nervous system development; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including inner ear morphogenesis; positive regulation of exit from mitosis; and regulation of neuron differentiation. Predicted to be located in perikaryon. Predicted to be active in nucleus. Orthologous to human NEUROG1 (neurogenin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Neurog1 in Genome Data Viewer
Location:
17p14
Exon count:
1
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (8362878..8364397)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9154656..9156175)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 14 Neighboring gene ribosomal protein L35, pseudogene 1 Neighboring gene uncharacterized LOC102547185 Neighboring gene uncharacterized LOC108348503

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in auditory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea development ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in craniofacial suture morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in genitalia development ISO
Inferred from Sequence Orthology
more info
 
involved_in genitalia morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in hard palate morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in learned vocalization behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in mastication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of relaxation of muscle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of saliva secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in peristalsis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of muscle organ development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in thorax and anterior abdomen determination ISO
Inferred from Sequence Orthology
more info
 
involved_in trigeminal nerve development ISO
Inferred from Sequence Orthology
more info
 
involved_in vestibulocochlear nerve formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neurogenin-1
Names
NGN-1
neurogenic basic-helix-loop-helix protein
neurogenic differentiation 3
neurogenic differentiation factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019207.2NP_062080.1  neurogenin-1

    See identical proteins and their annotated locations for NP_062080.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000284
    UniProtKB/Swiss-Prot
    P70595
    Related
    ENSRNOP00000015916.2, ENSRNOT00000015916.4
    Conserved Domains (1) summary
    cd19716
    Location:83154
    bHLH_TS_NGN1_NeuroD3; basic helix-loop-helix (bHLH) domain found in neurogenin-1 (NGN-1) and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    8362878..8364397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)