U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hells helicase, lymphoid specific [ Rattus norvegicus (Norway rat) ]

Gene ID: 294071, updated on 3-Jun-2026
Symbol
Hellsprovided by RGD
Full Name
helicase, lymphoid specificprovided by RGD
Primary source
RGD:1309820
See related
Ensembl:ENSRNOG00000047692 AllianceGenome:RGD:1309820
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in kidney development; lymphocyte proliferation; and negative regulation of gene expression, epigenetic. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; chromosomal DNA methylation maintenance following DNA replication; and negative regulation of intrinsic apoptotic signaling pathway. Predicted to be located in chromosome, centromeric region. Predicted to be active in nucleus and pericentric heterochromatin. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Thymus (RPKM 136.5), Spleen (RPKM 101.2) and 9 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Hells in Genome Data Viewer
Location:
1q53
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (246113580..246159230)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (236701704..236748239)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (257901856..257953889)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 12 Neighboring gene uncharacterized LOC134483995 Neighboring gene ribosomal protein L35A like 10 Neighboring gene ribosomal protein L27a, pseudogene 13 Neighboring gene cytochrome P450, subfamily 2, polypeptide 11

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin. Yan Q, et al. Mol Cell Biol, 2003 Dec. PMID 14612388, Free PMC Article
  2. Lsh, a member of the SNF2 family, is required for genome-wide methylation. Dennis K, et al. Genes Dev, 2001 Nov 15. PMID 11711429, Free PMC Article
  3. Lsh, a SNF2 family member, is required for normal murine development. Geiman TM, et al. Biochim Biophys Acta, 2001 May 3. PMID 11325543
  4. Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes. Geiman TM, et al. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781083, Free PMC Article
  5. Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3β-E2F1 Axis Linking Reversely with Survival in Gliomas. Xiao D, et al. Theranostics, 2017. PMID 28042322, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin-protein adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA methylation-dependent constitutive heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA methylation-dependent constitutive heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromosomal DNA methylation maintenance following DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in lymphocyte proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in pericentric heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pericentric heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within urogenital system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentric heterochromatin IEA
Inferred from Electronic Annotation
more info
  
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
lymphoid-specific helicase
Names
TBC1D12: TBC1 domain family, member 12
lymphocyte-specific helicase-like

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106371.1 → NP_001099841.1  lymphoid-specific helicase

    See identical proteins and their annotated locations for NP_001099841.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A0A0G2K7M6, A6I194, M0R3Y7, M0R5Q8
    Conserved Domains (4) summary
    COG0513
    Location:562 → 818
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00046
    Location:242 → 384
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:225 → 576
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:597 → 711
    Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    246113580..246159230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589048.3 → XP_017444537.1  lymphoid-specific helicase isoform X1

    UniProtKB/TrEMBL
    A0A0G2K7M6, A6I194, M0R3Y7, M0R5Q8
    Related
    ENSRNOP00000074269.2, ENSRNOT00000083183.3
    Conserved Domains (4) summary
    COG0513
    Location:562 → 818
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00046
    Location:242 → 384
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:225 → 576
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:597 → 711
    Helicase_C; Helicase conserved C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools