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GSTA3 glutathione S-transferase alpha 3 [ Homo sapiens (human) ]

Gene ID: 2940, updated on 13-Jan-2019

Summary

Official Symbol
GSTA3provided by HGNC
Official Full Name
glutathione S-transferase alpha 3provided by HGNC
Primary source
HGNC:HGNC:4628
See related
Ensembl:ENSG00000174156 MIM:605449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTA3; GSTA3-3
Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 10.7), placenta (RPKM 5.5) and 2 other tissues See more
Orthologs

Genomic context

See GSTA3 in Genome Data Viewer
Location:
6p12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (52896639..52909799, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52761437..52774496, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase alpha 11, pseudogene Neighboring gene uncharacterized LOC105375091 Neighboring gene glutathione S-transferase alpha 10, pseudogene Neighboring gene glutathione S-transferase alpha 9, pseudogene Neighboring gene glutathione S-transferase alpha 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22232

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
glutathione transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
glutathione S-transferase A3
Names
GST class-alpha member 3
S-(hydroxyalkyl)glutathione lyase A3
glutathione S-alkyltransferase A3
glutathione S-aralkyltransferase A3
glutathione S-aryltransferase A3
glutathione S-transferase A3-3
NP_000838.3
XP_006715135.1
XP_011512835.1
XP_024302182.1
XP_024302183.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000847.5NP_000838.3  glutathione S-transferase A3 isoform 1

    See identical proteins and their annotated locations for NP_000838.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI199811, AL121969, BC020619, DT932587
    Consensus CDS
    CCDS4947.1
    UniProtKB/Swiss-Prot
    Q16772
    Related
    ENSP00000211122.3, ENST00000211122.3
    Conserved Domains (3) summary
    PTZ00057
    Location:1198
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:482
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. NM_001363542.1NP_001350471.1  glutathione S-transferase A3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AF020919, AL121969
    Consensus CDS
    CCDS87412.1
    Conserved Domains (2) summary
    cd03208
    Location:36170
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:132
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    52896639..52909799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446415.1XP_024302183.1  glutathione S-transferase A3 isoform X1

    Related
    ENSP00000360007.1, ENST00000370968.5
    Conserved Domains (2) summary
    cd03208
    Location:36170
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:132
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_006715072.4XP_006715135.1  glutathione S-transferase A3 isoform X1

    See identical proteins and their annotated locations for XP_006715135.1

    UniProtKB/TrEMBL
    Q5JW85
    Conserved Domains (2) summary
    cd03208
    Location:36170
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:132
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. XM_024446414.1XP_024302182.1  glutathione S-transferase A3 isoform X1

    Conserved Domains (2) summary
    cd03208
    Location:36170
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:132
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  4. XM_011514533.2XP_011512835.1  glutathione S-transferase A3 isoform X2

    Conserved Domains (1) summary
    cd03208
    Location:1127
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases

RNA

  1. XR_926166.2 RNA Sequence

  2. XR_926167.2 RNA Sequence

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