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Flna filamin A [ Rattus norvegicus (Norway rat) ]

Gene ID: 293860, updated on 3-Jun-2018
Official Symbol
Flnaprovided by RGD
Official Full Name
filamin Aprovided by RGD
Primary source
RGD:1560614
See related
Ensembl:ENSRNOG00000054890
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560614
Expression
Biased expression in Uterus (RPKM 2133.5), Lung (RPKM 1473.2) and 9 other tissues See more
Orthologs
See Flna in Genome Data Viewer
Location:
Xq37
Exon count:
48
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156460785..156487245)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (152200936..152227391)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10 Neighboring gene emerin Neighboring gene transketolase-like 1 Neighboring gene testis expressed 28 Neighboring gene opsin 1, medium wave sensitive

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Fc-gamma receptor I complex binding IEA
Inferred from Electronic Annotation
more info
 
Fc-gamma receptor I complex binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Rac GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Rac GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Ral GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Ral GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Rho GTPase binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
cadherin binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding IEA
Inferred from Electronic Annotation
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
mu-type opioid receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin crosslink formation IEA
Inferred from Electronic Annotation
more info
 
actin crosslink formation ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex development IEP
Inferred from Expression Pattern
more info
PubMed 
cilium assembly IEA
Inferred from Electronic Annotation
more info
 
cilium assembly ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic sequestering of protein IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic sequestering of protein ISO
Inferred from Sequence Orthology
more info
 
early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
establishment of Sertoli cell barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
formation of radial glial scaffolds IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
mRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase I IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
protein localization to bicellular tight junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
receptor clustering IEA
Inferred from Electronic Annotation
more info
 
receptor clustering ISO
Inferred from Sequence Orthology
more info
 
regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane repolarization during cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
semaphorin-plexin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
wound healing, spreading of cells IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Myb complex IEA
Inferred from Electronic Annotation
more info
 
Myb complex ISO
Inferred from Sequence Orthology
more info
 
Z disc ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
actin filament bundle ISO
Inferred from Sequence Orthology
more info
 
apical dendrite IDA
Inferred from Direct Assay
more info
PubMed 
brush border ISO
Inferred from Sequence Orthology
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
filamentous actin IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with filamentous actin ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
filamin-A
Names
Endothelial actin-binding protein 280)
actin binding protein 280
filamin A, alpha
filamin, alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134599.1NP_001128071.1  filamin-A

    See identical proteins and their annotated locations for NP_001128071.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474099
    UniProtKB/TrEMBL
    C0JPT7
    Related
    ENSRNOP00000070703.1, ENSRNOT00000079889.1
    Conserved Domains (4) summary
    smart00033
    Location:172264
    CH; Calponin homology domain
    smart00557
    Location:20392128
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:44148
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:18581941
    Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    156460785..156487245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229569.3XP_006229631.1  filamin-A isoform X1

    Conserved Domains (4) summary
    smart00033
    Location:172264
    CH; Calponin homology domain
    smart00557
    Location:20472136
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:44148
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:18661949
    Filamin; Filamin/ABP280 repeat
  2. XM_006229570.3XP_006229632.1  filamin-A isoform X2

    See identical proteins and their annotated locations for XP_006229632.1

    UniProtKB/TrEMBL
    C0JPT7
    Conserved Domains (4) summary
    smart00033
    Location:172264
    CH; Calponin homology domain
    smart00557
    Location:20392128
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:44148
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:18581941
    Filamin; Filamin/ABP280 repeat

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    135865679..135888971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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